0000874015-14-000077.txt : 20140815 0000874015-14-000077.hdr.sgml : 20140815 20140815183911 ACCESSION NUMBER: 0000874015-14-000077 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20140813 FILED AS OF DATE: 20140815 DATE AS OF CHANGE: 20140815 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: CROOKE STANLEY T CENTRAL INDEX KEY: 0000897667 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 141047663 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0306 4 2014-08-13 0000874015 ISIS PHARMACEUTICALS INC ISIS 0000897667 CROOKE STANLEY T C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 1 0 0 Chairman, President and CEO Common Stock 2014-08-13 2014-08-13 4 M 0 15500 14.47 A 22441 D Common Stock 2014-08-13 2014-08-13 4 S 0 15500 35.454 D 6941 D Common Stock 2014-08-13 2014-08-13 4 M 0 1600 11.27 A 2227 I By Wife Common Stock 2014-08-13 2014-08-13 4 S 0 1600 35.454 D 627 I By Wife Common Stock 725391 I By Trust Employee Stock Option (right to buy) 14.47 2014-08-13 2014-08-13 4 M 0 15500 0 D 2013-01-02 2016-01-01 Common Stock 15500 36000 D Employee Stock Option (right to buy) 11.27 2014-08-13 2014-08-13 4 M 0 1600 0 D 2014-01-04 2017-01-03 Common Stock 1600 2200 I By Wife Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 8/6/13. Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person's wife on 8/6/13. /s/Stanley T. Crooke 2014-08-14