0000874015-13-000047.txt : 20130323 0000874015-13-000047.hdr.sgml : 20130323 20130322195634 ACCESSION NUMBER: 0000874015-13-000047 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20130321 FILED AS OF DATE: 20130322 DATE AS OF CHANGE: 20130322 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: O'NEIL PATRICK R. CENTRAL INDEX KEY: 0001564926 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 13712428 MAIL ADDRESS: STREET 1: C/O ISIS PHARMACEUTICALS, INC. STREET 2: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0306 4 2013-03-21 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001564926 O'NEIL PATRICK R. C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 SVP, Legal and General Counsel Common Stock 2013-03-21 2013-03-21 4 M 0 9000 14.18 A 10324 D Common Stock 2013-03-21 2013-03-21 4 S 0 9000 19.26 D 1324 D Employee Stock Option (right to buy) 14.18 2013-03-21 2013-03-21 4 M 0 9000 0 D 2013-01-01 2015-12-31 Common Stock 9000 16000 D Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/16/2012. /s/Patrick R. O'Neil 2013-03-22