0000874015-13-000031.txt : 20130214 0000874015-13-000031.hdr.sgml : 20130214 20130214203514 ACCESSION NUMBER: 0000874015-13-000031 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20130213 FILED AS OF DATE: 20130214 DATE AS OF CHANGE: 20130214 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: O'NEIL PATRICK R. CENTRAL INDEX KEY: 0001564926 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 13617245 MAIL ADDRESS: STREET 1: C/O ISIS PHARMACEUTICALS, INC. STREET 2: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0306 4 2013-02-13 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001564926 O'NEIL PATRICK R. C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 SVP, Legal & General Counsel Common Stock 2013-02-13 2013-02-13 4 M 0 900 8.00 A 2363 D Common Stock 2013-02-13 2013-02-13 4 S 0 900 14.17 D 1463 D Common Stock 2013-02-13 2013-02-13 4 M 0 5200 7.25 A 6663 D Common Stock 2013-02-13 2013-02-13 4 S 0 5200 14.17 D 1463 D Common Stock 2013-02-13 2013-02-13 4 S 0 139 14.17 D 1324 D Employee Stock Option (right to buy) 8.00 2013-02-13 2013-02-13 4 M 0 900 0 D 2011-09-01 2017-08-31 Common Stock 900 5800 D Employee Stock Option (right to buy) 7.25 2013-02-13 2013-02-13 4 M 0 5200 0 D 2013-01-03 2019-01-02 Common Stock 5200 14300 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 30, 2013. Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purhcase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on January 30, 2013. Grant of 9/1/2010 to reporting person of stock options under the Isis Pharamceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 9/1/2011. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 2,500 shares per year. The option is exercisable as to 2,741 shares on 2/13/2013. Grant of 1/3/2012 to reporting person of stock options under the isis Pharamceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. The option is exercisable as to 5,281 shares on 2/13/2013. /s/Patrick R. O'Neil 2013-02-15