0000874015-12-000030.txt : 20120625 0000874015-12-000030.hdr.sgml : 20120625 20120625205656 ACCESSION NUMBER: 0000874015-12-000030 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20120625 FILED AS OF DATE: 20120625 DATE AS OF CHANGE: 20120625 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: BERTHELSEN SPENCER R CENTRAL INDEX KEY: 0001181548 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 12925862 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0305 4 2012-06-25 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001181548 BERTHELSEN SPENCER R C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 0 0 0 Common Stock 2012-06-25 2012-06-25 4 M 0 300 8.15 A 29600 D Common Stock 2012-06-25 2012-06-25 4 S 0 300 11.48 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 200 8.15 A 29500 D Common Stock 2012-06-25 2012-06-25 4 S 0 200 11.49 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 300 8.15 A 29600 D Common Stock 2012-06-25 2012-06-25 4 S 0 300 11.493 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 200 8.15 A 29500 D Common Stock 2012-06-25 2012-06-25 4 S 0 200 11.50 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 500 8.15 A 29800 D Common Stock 2012-06-25 2012-06-25 4 S 0 500 11.51 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 228 8.15 A 29528 D Common Stock 2012-06-25 2012-06-25 4 S 0 228 11.53 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 205 8.15 A 29505 D Common Stock 2012-06-25 2012-06-25 4 S 0 205 11.54 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 495 8.15 A 29795 D Common Stock 2012-06-25 2012-06-25 4 S 0 495 11.55 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 700 8.15 A 30000 D Common Stock 2012-06-25 2012-06-25 4 S 0 700 11.56 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 3500 8.15 A 32800 D Common Stock 2012-06-25 2012-06-25 4 S 0 3500 11.58 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 1500 8.15 A 30800 D Common Stock 2012-06-25 2012-06-25 4 S 0 1500 11.582 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 100 8.15 A 29400 D Common Stock 2012-06-25 2012-06-25 4 S 0 100 11.59 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 1600 8.15 A 30900 D Common Stock 2012-06-25 2012-06-25 4 S 0 1600 11.60 D 29300 D Common Stock 2012-06-25 2012-06-25 4 M 0 172 8.15 A 29472 D Common Stock 2012-06-25 2012-06-25 4 S 0 172 11.62 D 29300 D Common Stock 70 I By Daughter Director Stock Option (right to buy) 8.15 2012-06-25 2012-06-25 4 M 0 10000 0 D 2006-07-01 2012-06-30 Common Stock 10000 0 D Acquired as a result of exercising a stock option that was scheduled to expire on 6/30/12. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/12. /s/B. Lynne Parshall 2012-06-25