0000874015-12-000023.txt : 20120522 0000874015-12-000023.hdr.sgml : 20120522 20120522195131 ACCESSION NUMBER: 0000874015-12-000023 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20120521 FILED AS OF DATE: 20120522 DATE AS OF CHANGE: 20120522 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: BERTHELSEN SPENCER R CENTRAL INDEX KEY: 0001181548 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 12862827 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0305 4 2012-05-21 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001181548 BERTHELSEN SPENCER R C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 0 0 0 Common Stock 2012-05-21 2012-05-21 4 M 0 2731 9.40 A 32031 D Common Stock 2012-05-21 2012-05-21 4 S 0 2731 9.42 D 29300 D Common Stock 2012-05-22 2012-05-22 4 M 0 17269 9.40 A 46569 D Common Stock 2012-05-22 2012-05-22 4 S 0 17269 9.56 D 29300 D Common Stock 70 I By Daughter.. Director Stock Option (right to buy) 9.40 2012-05-21 2012-05-21 4 M 0 2731 0 D 2006-05-31 2012-05-30 Common Stock 2731 17269 D Director Stock Option (right to buy) 9.40 2012-05-22 2012-05-22 4 M 0 17269 0 D 2006-05-31 2012-05-30 Common Stock 17269 0 D Acquired as a result of exercising a stock option that was scheduled to expire on 5/30/12. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 3/1/12. /s/B. Lynne Parshall 2012-05-22