-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, AObeueY5+FV0I0VY72cQ6RX29Q7Od1oYsmXPQrODmOop0FoEaSSNbZwa7fCfj+Zp Z7Q1ytKhIxpendOqnd+xQw== 0000874015-06-000028.txt : 20060322 0000874015-06-000028.hdr.sgml : 20060322 20060322195215 ACCESSION NUMBER: 0000874015-06-000028 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20060320 FILED AS OF DATE: 20060322 DATE AS OF CHANGE: 20060322 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: ECKER DAVID J CENTRAL INDEX KEY: 0001073388 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 06704784 BUSINESS ADDRESS: BUSINESS PHONE: 760-931-9200 MAIL ADDRESS: STREET 1: 1896 RUTHERFORD ROAD CITY: CARLSBAD STATE: CA ZIP: 92008 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 1896 RUTHERFORD ROAD CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 1896 RUTHERFORD ROAD CITY: CARLSBAD STATE: CA ZIP: 92008 4 1 edgar.xml PRIMARY DOCUMENT X0202 4 2006-03-20 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001073388 ECKER DAVID J C/O ISIS PHARMACEUTICALS, INC. 1896 RUTHERFORD ROAD CARLSBAD CA 92008 0 1 0 0 Vice President Common Stock 2006-03-20 2006-03-20 4 M 0 14032 5.15 A 14032 D Common Stock 2006-03-20 2006-03-20 4 S 0 5000 9.10 D 9032 D Common Stock 2006-03-20 2006-03-20 4 S 0 32 8.52 D 9000 D Common Stock 2006-03-20 2006-03-20 4 S 0 4000 9.00 D 5000 D Common Stock 2006-03-20 2006-03-20 4 S 0 2000 8.92 D 3000 D Common Stock 2006-03-20 2006-03-20 4 S 0 1000 9.10 D 2000 D Common Stock 2006-03-20 2006-03-20 4 S 0 2000 9.12 D 0 D Common Stock 2006-03-21 2006-03-21 4 M 0 12756 5.15 A 12756 D Common Stock 2006-03-21 2006-03-21 4 S 0 251 9.05 D 12505 D Common Stock 2006-03-21 2006-03-21 4 S 0 1411 9.03 D 11094 D Common Stock 2006-03-21 2006-03-21 4 S 0 1991 9.00 D 9103 D Common Stock 2006-03-21 2006-03-21 4 S 0 4901 9.01 D 4202 D Common Stock 2006-03-21 2006-03-21 4 S 0 3120 9.06 D 1082 D Common Stock 2006-03-21 2006-03-21 4 S 0 482 9.02 D 600 D Common Stock 2006-03-21 2006-03-21 4 S 0 600 9.07 D 0 D Common Stock 40989 I Trust Employee Stock Option (right to buy) 5.15 2006-03-20 2006-03-20 4 M 0 14032 0 D 2006-01-01 2008-12-31 Common Stock 14032 39544 D Employee Stock Option (right to buy) 5.15 2006-03-21 2006-03-21 4 M 0 12756 0 D 2006-01-01 2008-12-31 Common Stock 12756 26788 D The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 10-3-05 Stock option under the Isis Pharmaceuticals, Inc. 2000 Broad-Based Equity Incentive Plan. The option was fully vested as of the date of the reported exercise. /s/David J. Ecker 2006-03-22 -----END PRIVACY-ENHANCED MESSAGE-----