-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, FZnqaK/1FLwuunwtfyRVyrFLUGcCqx2TxJn2sZLXqJCMs3dQphYSgulp8V/BUDFl Oouskptd1cg7OZWZsoi7FQ== 0000874015-05-000013.txt : 20050611 0000874015-05-000013.hdr.sgml : 20050611 20050526193905 ACCESSION NUMBER: 0000874015-05-000013 CONFORMED SUBMISSION TYPE: 3 PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20050525 FILED AS OF DATE: 20050526 DATE AS OF CHANGE: 20050526 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Wedel Mark K CENTRAL INDEX KEY: 0001321261 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 05861357 BUSINESS ADDRESS: BUSINESS PHONE: 760-931-9200 MAIL ADDRESS: STREET 1: 1896 RUTHERFORD ROAD CITY: CARLSBAD STATE: CA ZIP: 92008 3 1 edgar.xml PRIMARY DOCUMENT X0202 3 2005-05-25 0 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001321261 Wedel Mark K 1896 RUTHERFORD ROAD CARLSBAD CA 92008 0 1 0 0 VP & Chief Medical Officer Common Stock 7204 D Employee Stock Option (right to buy) 6.59 2007-01-01 2012-12-31 Common Stock 25000 D Employee Stock Option (right to buy) 6.84 2007-01-02 2013-01-01 Common Stock 4500 D Employee Stock Option (right to buy) 5.15 2006-01-01 2008-12-31 Common Stock 10500 D Employee Stock Option (right to buy) 6.81 2008-01-02 2014-01-01 Common Stock 16781 D Employee Stock Option (right to buy) 5.80 2009-01-03 2012-01-02 Common Stock 20848 D Grant of 1-1-03 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2000 Broad-Based Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1-1-04. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 6,250 shares per year. The option is exercisable as to 14,583 shares on 5-25-05. Grant of 1-2-03 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2000 Broad-Based Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1-2-04. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 1,125 shares per year. The option is exercisable as to 2,625 shares on 5-25-05. Grant of 5-9-03 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 2000 Broad-Based Equity Incentive Plan. 33.34% of the shares subject to the option vested and became exercisable on 1-1-04. Thereafter, the remaining shares subject to the option vest and become exercisable in 24 equal monthly installments, at the rate of 3,500 shares per year. The option is exercisable as to 8,166 shares on 5-25-05. Grant of 1-2-04 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1-2-05. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,195 shares per year. The option is exercisable as to 5,594 shares on 5-25-05. Grant of 1-3-05 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option will vest and become exercisable on 1-3-06. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 5,212 shares per year. The option is exercisable as to 0 shares on 5-25-05. /s/Mark K. Wedel 2005-05-25 EX-24 2 wedelpoa.htm

POWER OF ATTORNEY



Know all by these presents, that the undersigned hereby constitutes and appoints each of Stanley T. Crooke and B. Lynne Parshall, signing individually, the undersigned's true and lawful attorneys-in fact and agents to:

(1) execute for and on behalf of the undersigned, an officer, director or holder of 10% or more of a registered class of securities of Isis Pharmaceuticals, Inc. (Isis), Forms 3, 4 and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended (the Exchange Act) and the rules thereunder;

(2) do and perform any and all acts for and on behalf of the undersigned that may be necessary or desirable to complete and execute such Form 3, 4 or 5, complete and execute any amendment or amendments thereto, and timely file such forms or amendments with the United States Securities and Exchange Commission and any stock exchange or similar authority; and

(3) take any other action of any nature whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.

The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, will lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted.  The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is Isis assuming, any of the undersigned's responsibilities to comply with Section 16 of the Exchange Act.

This Power of Attorney shall remain in full force and effect until the earliest to occur of (a) the undersigned is no longer required to file Forms 3, 4 and 5 with respect to the undersigned's holdings of and transactions in securities issued by Isis, (b) revocation by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact or (c) as to any attorney-in-fact individually, until such attorney-in-fact will no longer be employed by Isis.



IN WITNESS WHEREOF, the undersigned has cause this Power of Attorney to be executed as of this 25th day of May, 2005.







/s/Mark K Wedel

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