-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, NVCwmjHgRfFQubbbuiZkEIuo57ZktKoa8SBqfcoTrlGPNasfIAD6F8isjvRLmyGE uRKQV87QklwED6Dhd0jqQA== 0000874015-04-000071.txt : 20041206 0000874015-04-000071.hdr.sgml : 20041206 20041206194346 ACCESSION NUMBER: 0000874015-04-000071 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20041202 FILED AS OF DATE: 20041206 DATE AS OF CHANGE: 20041206 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: CROOKE STANLEY T CENTRAL INDEX KEY: 0000897667 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 041187208 BUSINESS ADDRESS: STREET 1: C/O ISIS PHARMACEUTICALS INC STREET 2: 2292 FARADAY AVENUE CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 6196032301 MAIL ADDRESS: STREET 1: 2292 FARADAY AVENUE CITY: CARLSBAD STATE: CA ZIP: 92008 4 1 edgar.xml PRIMARY DOCUMENT X0202 4 2004-12-02 0000874015 ISIS PHARMACEUTICALS INC ISIS 0000897667 CROOKE STANLEY T 2292 FARADAY AVENUE CARLSBAD CA 92008 1 1 0 0 Chairman, President, CEO Common Stock 2004-12-02 2004-12-02 4 M 0 12304 4.00 A 934545 D Common Stock 2004-12-02 2004-12-02 4 S 0 12304 5.4527 D 922241 D Common Stock 2004-12-03 2004-12-03 4 M 0 7000 4.00 A 929241 D Common Stock 2004-12-03 2004-12-03 4 S 0 7000 6.317 D 922241 D Common Stock 2004-12-06 2004-12-06 4 M 0 4000 4.00 A 926241 D Common Stock 2004-12-06 2004-12-06 4 S 0 4000 5.7259 D 922241 D Common Stock 1050 I By Wife Employee Stock Option (right to buy) 4.00 2004-12-02 2004-12-02 4 M 0 7051 0 D 2000-01-01 2004-12-31 Common Stock 7051 0 D Employee Stock Option (right to buy) 4.00 2004-12-02 2004-12-02 4 M 0 5253 0 D 2000-01-01 2004-12-31 Common Stock 5253 19747 D Employee Stock Option (right to buy) 4.00 2004-12-03 2004-12-03 4 M 0 7000 0 D 2000-01-01 2004-12-31 Common Stock 7000 12747 D Employee Stock Option (right to buy) 4.00 2004-12-06 2004-12-06 4 M 0 4000 0 D 2000-01-01 2004-12-31 Common Stock 4000 8747 D Acquired as a result of exercising a stock option that was scheduled to expire on 12-31-04. The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 9-30-04. Stanley T. Crooke 2004-12-06 -----END PRIVACY-ENHANCED MESSAGE-----