-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 NH4PZyRSvXL2HBwPKstozhPEYrBhsRD9SC5iARMMWU2S3rQVYLQsB+yCRoh6dexl
 nx9i4omjV3lg9pgy4UvL2Q==

<SEC-DOCUMENT>0000000000-07-027297.txt : 20070919
<SEC-HEADER>0000000000-07-027297.hdr.sgml : 20070919
<ACCEPTANCE-DATETIME>20070601161427
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0000000000-07-027297
CONFORMED SUBMISSION TYPE:	UPLOAD
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20070601

FILED FOR:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		UPLOAD

	BUSINESS ADDRESS:	
		STREET 1:		1896 RUTHERFORD ROAD
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		1896 RUTHERFORD ROAD
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
PUBLIC REFERENCE ACCESSION NUMBER:		0001104659-07-019915
</SEC-HEADER>
<DOCUMENT>
<TYPE>LETTER
<SEQUENCE>1
<FILENAME>isisltr.pdf
<DESCRIPTION>6/1/07 COMM. LTR.- 2006 FORM 10-K (TARG. REV.) FILED 3/16/07; BRUCKNER/MAST
<TEXT>
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