X0202 4 2007-06-18 1 0000873591 MEDIMMUNE INC /DE MEDI 0001315038 Machielse Bernardus N M ONE MEDIMMUNE WAY GAITHERSBURG MD 20878 0 1 0 0 EVP, Operations Stock Option (right to buy) 38.68 2007-06-18 4 D 0 22500 0 D 2011-02-15 Common Stock 22500 0 D Stock Option (right to buy) 41.41 2007-06-18 4 D 0 24000 0 D 2012-02-21 Common Stock 24000 0 D Stock Option (right to buy) 29.34 2007-06-18 4 D 0 30000 0 D 2013-02-20 Common Stock 30000 0 D Stock Option (right to buy) 34.70 2007-06-18 4 D 0 15000 0 D 2013-09-01 Common Stock 15000 0 D Stock Option (right to buy) 23.45 2007-06-18 4 D 0 50000 0 D 2014-03-04 Common Stock 50000 0 D Stock Option (right to buy) 24.09 2007-06-18 4 D 0 20000 0 D 2015-01-26 Common Stock 20000 0 D Stock Option (right to buy) 24.17 2007-06-18 4 D 0 75000 0 D 2015-02-15 Common Stock 75000 0 D Stock Option (right to buy) 36.78 2007-06-18 4 D 0 70000 0 D 2016-02-22 Common Stock 70000 0 D Stock Option (right to buy) 33.43 2007-06-18 4 D 0 20000 0 D 2016-11-07 Common Stock 20000 0 D Stock Option (right to buy) 31.25 2007-06-18 4 D 0 65000 0 D 2017-02-14 Common Stock 65000 0 D This option, which provided for vesting in equal quarterly installments beginning 05/15/2001, was cancelled pursuant to the merger agreement between the issuer and AstraZeneca PLC in exchange for a cash payment of $19.32 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 05/21/2002, was cancelled in the merger in exchange for a cash payment of $16.59 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 05/20/2003, was cancelled in the merger in exchange for a cash payment of $28.66 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 12/01/2003, was cancelled in the merger in exchange for a cash payment of $23.30 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 06/04/2004, was cancelled in the merger in exchange for a cash payment of $34.55 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 04/27/2005, was cancelled in the merger in exchange for a cash payment of $33.91 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 05/16/2005, was cancelled in the merger in exchange for a cash payment of $33.83 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 05/23/2006, was cancelled in the merger in exchange for a cash payment of $21.22 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 02/08/2007, was cancelled in the merger in exchange for a cash payment of $24.57 per share, representing the difference between the exercise price of the option and $58.00 per share. This option, which provided for vesting in equal quarterly installments beginning 05/15/2007, was cancelled in the merger in exchange for a cash payment of $26.75 per share, representing the difference between the exercise price of the option and $58.00 per share. /s/ William C. Bertrand, Jr., Attorney-in-Fact 2007-06-19