Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenues:
Products, net	$ 141,839	$ 111,344	$ 266,765	$ 211,792
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration	$ 22,250	$ 26,019	$ 44,255	$ 39,245
Total revenues	164,089	137,363	311,020	251,037
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	19,515	13,341	41,861	25,963
Research and development	239,622	188,522	434,771	324,666
Selling, general and administrative	72,347	73,688	143,478	156,456
Settlement and license charges			10,000
Amortization of in-licensed rights	179	165	349	331
Total cost and expenses	331,663	275,716	630,459	507,416
Operating loss	(167,574)	(138,353)	(319,439)	(256,379)
Other income (loss):
Gain from sale of Priority Review Voucher	102,000		102,000	108,069
Other expense, net	(16,185)	(12,447)	(31,713)	(19,867)
Total other income (loss)	85,815	(12,447)	70,287	88,202
Loss before income tax (benefit) expense	(81,759)	(150,800)	(249,152)	(168,177)
Income tax (benefit) expense	(354)	20	(497)	135
Net loss	(81,405)	(150,820)	(248,655)	(168,312)
Other comprehensive loss:
Unrealized gains (losses) on investments, net of tax	5	(618)	(1)	(44)
Total other comprehensive loss	5	(618)	(1)	(44)
Comprehensive loss	$ (81,400)	$ (151,438)	$ (248,656)	$ (168,356)
Net loss per share - basic and diluted	$ (1.02)	$ (1.93)	$ (3.12)	$ (2.18)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	79,746	77,968	79,601	77,200