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Summary of Other Non-current Assets (Detail) - USD ($)
$ in Thousands
Mar. 31, 2019
Dec. 31, 2018
Prepaid Expense And Other Assets Noncurrent [Abstract]    
Manufacturing-related deposits $ 82,961 $ 62,821
Strategic investments 32,359 31,739
Restricted cash and investments 6,201 1,001
Prepaid clinical expenses 5,700 7,541
Alternative minimum tax credit 3,367 3,367
Other 2,725 825
Total other non-current assets $ 133,313 $ 107,294