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Summary of Aggregate Non-Cancelable Contractual Obligations Arising from Manufacturing Obligations (Detail)
$ in Thousands
Sep. 30, 2018
USD ($)
Commitments And Contingencies Disclosure [Abstract]  
2018 (September - December) $ 45,463
2019 78,720
2020 45,940
2021 32,000
2022 40,000
Thereafter 160,000
Total manufacturing commitments $ 402,123