X0306 4 2023-03-06 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001848718 Brown Ryan Edward 215 FIRST STREET CAMBRIDGE MA 02124 0 1 0 0 SVP, General Counsel Common Stock 2023-03-06 4 F 0 1154 157.21 D 24491 D Common Stock 2023-03-06 4 F 0 171 157.21 D 24320 D Common Stock 2023-03-06 4 A 0 4500 0.00 A 28820 D Stock Option (right to buy) 155.99 2023-03-06 4 A 0 27000 0.00 A 2024-03-06 2033-03-06 Common Stock 27000 27000 D Shares were withheld by the Company to satisfy tax withholding obligations related to vesting of restricted stock units granted on March 3, 2021. Shares were withheld by the Company to satisfy tax withholding obligations related to vesting of restricted stock units granted on March 4, 2019. The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock. 25% of the shares of common stock underlying each RSU will vest on the first anniversary of the grant date, and additional 25% will vest on each anniversary of the Grant Date thereafter, such that the RSUs will be fully vested on the fourth anniversary of the grant date. Represents the date upon which the first 25% of the option granted vests. 1/48th of the total granted option vests and become exercisable on each monthly anniversary thereafter. /s/ Ryan Brown 2023-03-08