X0306 4 2020-08-07 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001562371 Barry Richard 215 FIRST STREET, SUITE 415 CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2020-08-07 4 S 0 26860 158.43 D 3132280 D Common Stock 2020-08-07 4 S 0 3140 159.09 D 3129140 D The shares were sold in transactions at prices ranging from $158.00 to $159.00, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The shares were sold in transactions at prices ranging from $159.01 to $159.17, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. /s/ David Tyronne Howton, as Attorney-in-Fact for Richard Barry 2020-08-07