X0306 4 2020-06-22 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001529297 Howton David T 215 FIRST STREET, SUITE 415 CAMBRIDGE MA 02142 0 1 0 0 EVP, General Counsel Common Stock 2020-06-22 4 M 0 1280 13.71 A 33151 D Common Stock 2020-06-22 4 M 0 1858 13.71 A 35009 D Common Stock 2020-06-22 4 M 0 56984 23.85 A 91993 D Common Stock 2020-06-22 4 M 0 45000 29.03 A 136993 D Common Stock 2020-06-22 4 S 0 6009 168.61 D 130984 D Common Stock 2020-06-22 4 S 0 8086 169.56 D 122898 D Common Stock 2020-06-22 4 S 0 35757 170.59 D 87141 D Common Stock 2020-06-22 4 S 0 55270 171.50 D 31871 D Stock option (right to buy) 13.71 2020-06-22 4 M 0 1280 0.00 D 2017-02-28 2026-02-28 Common Stock 1280 0 D Stock option (right to buy) 13.71 2020-06-22 4 M 0 1858 0.00 D 2017-02-28 2026-02-28 Common Stock 1858 0 D Stock option (right to buy) 23.85 2020-06-22 4 M 0 56984 0.00 D 2013-11-05 2022-11-05 Common Stock 56984 0 D Stock option (right to buy) 29.03 2020-06-22 4 M 0 45000 0.00 D 2015-02-28 2024-02-28 Common Stock 45000 7708 D This transaction was effected pursuant to a Rule 10b5-1 Plan adopted by the reporting person. Accordingly, the reporting person had no discretion with regards to the timing of the transaction. The shares were sold in transactions at prices ranging from $168.04 to $169.0399, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The shares were sold in transactions at prices ranging from $169.09 to $170.0899, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The shares were sold in transactions at prices ranging from $170.09 to $171.0899, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The shares were sold in transactions at prices ranging from $171.09 to $172.0899, inclusive. The reporting person undertakes to provide to Sarepta Therapeutics, Inc., any security holder of Sarepta Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. /s/ David Tyronne Howton 2020-06-22