X0306 4 2020-02-28 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001529297 Howton David T 215 FIRST STREET, SUITE 415 CAMBRIDGE MA 02142 0 1 0 0 EVP, General Counsel Common Stock 2020-02-28 4 A 0 6700 0.00 A 31871 D Stock option (right to buy) 114.47 2020-02-28 4 A 0 37500 0.00 A 2030-02-28 Common Stock 37500 37500 D The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock. 25% of the shares of common stock underlying each RSU will vest and become exercisable on the first anniversary of the grant date, and additional 25% will vest and become exercisable on each anniversary of the Grant Date thereafter, such that the RSUs will be fully vested and exercisable on the fourth anniversary of the grant date. 25% of the option granted vests and is exercisable on the first anniversary of the date of grant and 1/48th of the total granted option will vest and become exercisable on each monthly anniversary thereafter, such that the option will be fully vested and exercisable on the fourth anniversary of the date of grant. /s/ David Tyronne Howton 2020-02-28