X0306 4 2018-03-15 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001685986 Ruff Shamim 215 FIRST STREET SUITE 415 CAMBRIDGE MA 02142 0 1 0 0 SVP, Chief Regulatory Affairs Common Stock 2018-03-15 4 M 0 469 13.90 A 27514 D Common Stock 2018-03-15 4 F 0 80 81.22 D 27434 D Common Stock 2018-03-15 4 M 0 2031 26.24 A 29465 D Common Stock 2018-03-15 4 F 0 656 81.22 D 28809 D Stock option (right to buy) 13.90 2018-03-15 4 M 0 469 0.00 D 2016-02-27 2025-02-27 Common Stock 469 6134 D Stock option (right to buy) 26.24 2018-03-15 4 M 0 2031 0.00 D 2014-01-02 2023-01-02 Common Stock 2031 10066 D The Reporting Person delivered already-owned shares of Common Stock in payment of the option exercise price. Such an "option swap" enables the exercise and holding of shares of Common Stock by the Reporting Person. /s/ David Tyronne Howton, as Attorney-in-Fact for Shamim Ruff 2018-03-16