X0306 4 2018-03-05 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001717540 Basi Guriqbal S. 215 FIRST STREET SUITE 415 CAMBRIDGE MA 02142 0 1 0 0 SVP, Chief Scientific Officer Stock option (right to buy) 71.45 2018-03-05 4 A 0 70000 0.00 A 2028-03-05 Common Stock 70000 70000 D 25% of the option granted vests and is exercisable on the first anniversary of the date of grant and 1/48th of the total granted option will vest and become exercisable on each monthly anniversary thereafter, such that the option will be fully vested and exercisable on the fourth anniversary of the date of grant. /s/ David Tyronne Howton 2018-03-07