X0306 4 2018-03-05 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001562371 Barry Richard 215 FIRST STREET, SUITE 415 CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2018-03-05 4 A 0 3418 0.00 A 3245432 D Stock option (right to buy) 71.45 2018-03-05 4 A 0 4820 0.00 A 2028-03-05 Common Stock 4820 4820 D Each restricted stock award represents the right to receive one share of common stock and will vest in full on the first year anniversary of the Issuer's 2018 Annual Meeting of Stockholders. The option will vest at a rate of 1/24th of the total option amount granted on a monthly basis over two years commencing on the first monthly anniversary of the Issuer's 2018 Annual Meeting of Stockholders. /s/ David Tyronne Howton 2018-03-07