CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2026	Sep. 30, 2025	Sep. 30, 2026	Sep. 30, 2025
Revenues:
Products, net	$ 323,763	$ 370,043	$ 982,967	$ 1,494,689
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration and other	$ 57,588	$ 29,313	$ 530,438	$ 260,614
Total revenues	381,351	399,356	1,513,405	1,755,303
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	188,512	150,775	446,665	440,897
Research and development	82,549	218,890	327,767	1,196,730
Selling, general and administrative	118,612	91,893	335,163	363,419
Litigation contingency charge	0	0	39,000	0
Restructuring Charges	0	40,510	0	40,510
Amortization of in-licensed rights	718	677	2,126	1,945
Total cost and expenses	390,391	502,745	1,150,721	2,043,501
Operating (loss) income	(9,040)	(103,389)	362,684	(288,198)
Other (loss) income, net:
Other (expense) income, net	(16,726)	34,958	(47,025)	(10,113)
Gain on debt extinguishment	0	3,761	0	3,761
Total other (loss) income, net	(16,726)	38,719	(47,025)	(6,352)
(Loss) income before income tax expense (benefit)	(25,766)	(64,670)	315,659	(294,550)
Income tax expense (benefit)	2,695	(14,102)	18,051	6,634
Net (loss) income	(28,461)	(50,568)	297,608	(301,184)
Other comprehensive (loss) income:
Unrealized (losses) gains on investments, net of tax	(1,021)	271	(1,858)	438
Total other comprehensive (loss) income	(1,021)	271	(1,858)	438
Comprehensive (loss) income	$ (29,482)	$ (50,297)	$ 295,750	$ (300,746)
(Loss) earnings per share:
Basic	$ (0.27)	$ (0.5)	$ 2.82	$ (3.06)
Diluted	$ (0.27)	$ (0.5)	$ 2.78	$ (3.06)
Weighted average number of shares of common stock used in computing (loss) earnings per share:
Basic	105,930,000	100,237,000	105,453,000	98,545,000
Diluted	105,930,000	100,237,000	107,646,000	98,545,000