Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024		Dec. 31, 2023		Dec. 31, 2022
Cash flows from operating activities:
Net loss	$ 235,239		$ (535,977)		$ (703,488)
Adjustments to reconcile net loss to cash flows in operating activities:
Depreciation and amortization	37,724		44,397		41,864
Reduction in the carry amounts of the right of use assets	16,167		14,495		12,735
Non-cash interest expense	4,951		5,156		7,552
Stock-based compensation	184,300		182,514		233,018
Accretion of investment discount, net	(40,277)		(46,176)		(10,651)
Non-cash termination charges	62,747		0		0
Non-cash change in the fair value of derivatives	7,838		1,200		(6,700)
Impairment of strategic investments	0		30,321		2,575
Loss on debt extinguishment	0		387,329		125,441
Gain from sale of Priority Review Voucher	0		(102,000)		0
Other	2,130		(1,163)		11,778
Changes in operating assets and liabilities, net:
Increase in accounts receivable	(201,661)		(185,699)		(61,638)
(Increase) decrease in manufacturing-related deposits and prepaids	(188,588)		(12,521)		42,557
Increase in inventory	(395,170)		(147,714)		(50,780)
(Increase) decrease in other assets	(9,676)		1,808		(27,937)
Decrease in deferred revenue	(32,160)		(86,828)		(89,244)
Increase (decrease) in accounts payable, accrued expenses, lease liabilities and other liabilities	110,649		(50,135)		147,572
Net cash used in operating activities	(205,787)		(500,993)		(325,346)
Cash flows from investing activities:
Purchase of property and equipment	(136,956)		(76,106)		(30,824)
Purchase of available-for-sale securities	(1,099,595)		(2,044,940)		(1,936,856)
Maturity and sale of available-for-sale securities	2,002,112		1,868,482		923,224
Purchase of intangible assets	(10,000)		(11,239)		(1,427)
Acquisition of strategic investments	0		(4,000)		(1,000)
Proceeds from sale of Priority Review Voucher	0		102,000		0
Net cash provided by (used in) investing activities	755,561		(165,803)		(1,046,883)
Cash flows from financing activities:
Settlement of capped call share options for 2024 Notes	45,349		80,645		26,317
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	79,525		51,246		30,043
Payment on maturity of 2024 Notes	(68)		0		0
Debt conversion costs for 2024 Notes	0		(6,887)		0
Proceeds from 2027 Notes offering, net of commissions	0		0		1,127,400
Purchase of capped call share options for 2027 Notes	0		0		(127,305)
Debt issuance costs for 2027 Notes	0		0		(716)
Repurchase of 2024 Notes	0		0		(247,868)
Repayment of principal amount due under 2019 Term Loan	0		0		(550,000)
Payment on debt extinguishment of 2019 Term Loan	0		0		(25,364)
Net cash provided by financing activities	124,806		125,004		232,507
Increase (decrease) in cash and cash equivalents	674,580		(541,792)		(1,139,722)
Cash, cash equivalents and restricted cash:
Beginning of year	444,009		985,801		2,125,523
End of year	1,118,589		444,009		985,801
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	1,103,010		428,430		966,777
Restricted cash in other assets	15,579	[1]	15,579	[1]	19,024
Total cash, cash equivalents and restricted cash	1,118,589		444,009		985,801
Supplemental disclosure of cash flow information:
Cash paid during the period for interest	15,856		15,923		44,418
Cash paid during the period for income taxes	22,587		15,081		1,695
Supplemental schedule of non-cash activities:
Common stock issued for conversion or exchange of 2024 Notes	105,757		693,377		0
Intangible assets and property and equipment included in accounts payable and accrued expenses	42,740		33,339		6,765
Lease liabilities arising from obtaining right of use assets	35,361		80,203		40,006
Capitalized stock-based compensation and depreciation as inventory	28,549		0		0
Lease liabilities terminated	$ 2,381		$ 0		$ 3,807

[1] The Company had approximately $15.6 million in restricted cash included in other non-current assets on the Company's consolidated balance sheets as of December 31, 2024 and 2023. Restricted cash for both years relates to (i) letters of credit established under the Company's various property leases that serve as security for potential future default of lease payments, (ii) a letter of credit established under a certain commercial supply agreement and (iii) collateralized cash for the Company's credit cards. The restricted cash is unavailable for withdrawal or use for general obligations.