SEGMENT INFORMATION (Tables)

12 Months Ended

Dec. 31, 2024

Segment Reporting [Abstract]

Schedule of Company`s segment, including segment expenses, and a reconciliation to net income (loss)

The table below includes information about the Company’s segment, including significant segment expenses, and a reconciliation to net income (loss):

	For the Year Ended December 31,
	2024			2023			2022
	(in thousands)
Total revenues	$	1,901,979		$	1,243,336		$	933,013
Segment expenses and other segment items
Cost of sales (excluding amortization of in-licensed rights)		319,099			150,343			139,989
Compensation and other personnel expenses		335,830			319,080			256,382
Manufacturing expenses		329,011			345,826			466,111
Clinical trial expenses		163,565			187,289			135,838
Facility- and technology-related expenses (excluding depreciation and amortization)		106,281			88,559			71,700
Research and development- other (excluding non-cash items) (a)		108,597			118,727			117,171
Selling, general and administrative- other (excluding non-cash items) (b)		226,598			181,310			124,948
Roche collaboration reimbursement		(127,107	)		(106,885	)		(117,807	)
Other segment items (c)		(30,449	)		(49,129	)		(11,014	)
Interest expense		18,391			22,010			53,248
Interest income		(30,635	)		(36,257	)		(16,488	)
Income tax expense		25,535			15,879			13,525
Depreciation and amortization expense		37,724			44,397			41,864
Stock-based compensation expense		184,300			182,514			233,018
Gain from sale of Priority Review Voucher		—			(102,000	)		—
Impairment of strategic investments		—			30,321			2,575
Loss on debt extinguishment		—			387,329			125,441
Segment net income (loss)	$	235,239		$	(535,977	)	$	(703,488	)
Reconciliation of profit or loss
Adjustments and reconciling items		—			—			—
Consolidated net income (loss)	$	235,239		$	(535,977	)	$	(703,488	)

(a) Research and development-other includes professional services, up-front, milestone, and other expenses, pre-clinical expenses and research and other expenses.

(b) Selling, general and administrative-other includes professional services and other expenses.

(c) Other segment items included in segment net income (loss) include accretion of investment discount, net, change in fair value of derivatives and other, net, as well as the items separately presented and not defined as significant expenses below.