Consolidated Statements of Comprehensive Income (Loss) - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues:
Products, net	$ 1,787,960	$ 1,144,876	$ 843,769
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration and other	$ 114,019	$ 98,460	$ 89,244
Total revenues	1,901,979	1,243,336	933,013
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	319,099	150,343	139,989
Research and development	804,522	877,387	877,090
Selling, general and administrative	557,872	481,871	451,421
Amortization of in-licensed rights	2,405	1,559	714
Total cost and expenses	1,683,898	1,511,160	1,469,214
Operating income (loss)	218,081	(267,824)	(536,201)
Other (loss) income, net:
Other income (expense), net	42,693	33,055	(28,321)
Loss on debt extinguishment	0	(387,329)	(125,441)
Gain from sale of Priority Review Voucher	0	102,000	0
Total other income (loss), net	42,693	(252,274)	(153,762)
Income (loss) before income tax expense	260,774	(520,098)	(689,963)
Income tax expense	25,535	15,879	13,525
Net income (loss)	235,239	(535,977)	(703,488)
Other comprehensive income (loss):
Unrealized (losses) gains on investments, net of tax	(1,136)	2,582	(1,644)
Total other comprehensive (loss) income	(1,136)	2,582	(1,644)
Comprehensive income (loss)	$ 234,103	$ (533,395)	$ (705,132)
Earnings (loss) per share:
Basic	$ 2.47	$ (5.8)	$ (8.03)
Diluted	$ 2.34	$ (5.8)	$ (8.03)
Weighted average number of shares of common stock used in computing earnings (loss) per share:
Basic	95,075	92,398	87,559
Diluted	107,875	92,398	87,559