Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024		Sep. 30, 2023
Cash flows from operating activities:
Net income (loss)	$ 76,190		$ (581,632)
Adjustments to reconcile net income (loss) to cash flows from operating activities:
Depreciation and amortization	27,269		33,025
Reduction in the carrying amounts of the right of use assets	12,289		10,636
Non-cash interest expense	3,747		3,919
Stock-based compensation	134,624		136,688
Accretion of investment discount, net	(33,474)		(32,847)
Non-cash termination charges	62,747		0
Non-cash change in the fair value of derivatives	8,565		1,200
Impairment of equity investments	0		27,821
Loss on debt extinguishment	0		387,329
Gain from sale of Priority Review Voucher	0		(102,000)
Other	1,822		324
Changes in operating assets and liabilities, net:
Increase in accounts receivable	(34,197)		(104,227)
(Increase) decrease in manufacturing-related deposits and prepaids	(235,544)		7,897
Increase in inventory	(233,511)		(53,610)
Increase in other assets	(39,380)		(2,886)
Decrease in deferred revenue	(35,415)		(66,750)
Decrease in accounts payable, accrued expenses, lease liabilities and other liabilities	(13,565)		(111,223)
Net cash used in operating activities	(297,833)		(446,336)
Cash flows from investing activities:
Purchase of property and equipment	(98,874)		(57,067)
Purchase of available-for-sale securities	(936,684)		(1,475,404)
Maturity and sale of available-for-sale securities	1,037,001		1,340,265
Purchase of intangible assets	(10,000)		(11,239)
Proceeds from sale of Priority Review Voucher	0		102,000
Net cash provided by investing activities	(8,557)		(101,445)
Cash flows from financing activities:
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	75,815		49,303
Partial settlement of capped call share options for 2024 Notes	0		80,645
Debt conversion costs for 2024 Notes	0		(6,887)
Net cash provided by financing activities	75,815		123,061
Decrease in cash, cash equivalents and restricted cash	(230,575)		(424,720)
Cash, cash equivalents and restricted cash:
Beginning of period	444,009		985,801
End of period	213,434		561,081
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	197,855		541,932
Restricted cash in other assets	15,579	[1]	19,149
Total cash, cash equivalents and restricted cash	213,434		561,081
Supplemental disclosure of cash flow information:
Cash paid during the period for income taxes	11,614		9,569
Cash paid during the period for interest	15,169		15,129
Supplemental schedule of non-cash activities:
Modification of 2017 Capped Calls	43,887		0
Intangible assets and property and equipment included in accounts payable and accrued expenses	33,841		16,059
Lease liabilities arising from obtaining right of use assets	20,367		79,846
Common stock issued for exchange of 2024 Notes	14,185		693,377
Proceeds from exercise of stock options not yet received	475		0
Capitalized stock-based compensation and depreciation as inventory	$ 20,736		$ 0

[1] * The Company had approximately $15.6 million in restricted cash included in other non-current assets on the Company’s unaudited condensed consolidated balance sheets as of both September 30, 2024 and December 31, 2023. Restricted cash for both periods relates to (i) letters of credit established under the Company’s various property leases that serve as security for potential future default of lease payments, (ii) a letter of credit established under a certain commercial supply agreement and (iii) collateralized cash for the Company’s credit cards. The restricted cash is unavailable for withdrawal or use for general obligations.