Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (535,977)	$ (703,488)	$ (418,780)
Adjustments to reconcile net loss to cash flows in operating activities:
Loss on debt extinguishment	387,329	125,441	0
Gain from sale of Priority Review Voucher	(102,000)	0	(102,000)
Depreciation and amortization	44,397	41,864	38,017
Reduction in the carry amounts of the right of use assets	14,495	12,735	11,325
Non-cash interest expense	5,156	7,552	7,581
Stock-based compensation	182,514	233,018	113,943
Accretion of investment discount, net	(46,176)	(10,651)	(102)
Impairment of strategic investments	30,321	2,575	4,488
Other	37	5,078	522
Changes in operating assets and liabilities, net:
Net increase in accounts receivable	(185,699)	(61,638)	(51,650)
Net increase in inventory	(147,714)	(50,780)	(83,772)
Net (increase) decrease in other assets	(10,713)	14,620	103,203
Net decrease in deferred revenue	(86,828)	(89,244)	(89,244)
Net (decrease) increase in accounts payable, accrued expenses, lease liabilities and other liabilities	(50,135)	147,572	23,297
Net cash used in operating activities	(500,993)	(325,346)	(443,172)
Cash flows from investing activities:
Proceeds from sale of Priority Review Voucher	102,000	0	102,000
Purchase of property and equipment	(76,106)	(30,824)	(38,490)
Purchase of available-for-sale securities	(2,044,940)	(1,936,856)	(29,988)
Maturity and sale of available-for-sale securities	1,868,482	923,224	466,000
Purchase of intangible assets	(11,239)	(1,427)	(2,309)
Acquisition of strategic investments	(4,000)	(1,000)	(1,800)
Net cash (used in) provided by investing activities	(165,803)	(1,046,883)	495,413
Cash flows from financing activities:
Partial settlement of capped call share options for 2024 Notes	80,645	26,317	0
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	51,246	30,043	20,802
Debt conversion costs for 2024 Notes	(6,887)	0	0
Proceeds from 2027 Notes offering, net of commissions	0	1,127,400	0
Debt issuance costs for 2027 Notes	0	(716)	0
Purchase of capped call share options for 2027 Notes	0	(127,305)	0
Repurchase of 2024 Notes	0	(247,868)	0
Repayment of principal amount due under 2019 Term Loan	0	(550,000)	0
Payment on debt extinguishment of 2019 Term Loan	0	(25,364)	0
Taxes paid related to net share settlement of equity awards	0	0	(7,765)
Proceeds from sales of common stock, net of offering costs	0	0	548,532
Net cash provided by financing activities	125,004	232,507	561,569
(Decrease) increase in cash and cash equivalents	(541,792)	(1,139,722)	613,810
Cash, cash equivalents and restricted cash:
Beginning of year	985,801	2,125,523	1,511,713
End of year	444,009	985,801	2,125,523
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	428,430	966,777	2,115,869
Restricted cash in other assets	15,579	19,024	9,654
Total cash, cash equivalents and restricted cash	444,009	985,801	2,125,523
Supplemental disclosure of cash flow information:
Cash paid during the period for interest	15,923	44,418	55,949
Cash paid during the period for income taxes	15,081	1,695	583
Supplemental schedule of non-cash activities:
Lease liabilities arising from obtaining right of use assets	80,203	40,006	13,225
Intangible assets and property and equipment included in accounts payable and accrued expenses	33,339	6,765	4,162
Lease liabilities terminated	$ 0	$ 3,807	$ 40,133