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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001260768-10-000001.txt : 20101108
<SEC-HEADER>0001260768-10-000001.hdr.sgml : 20101108
<ACCEPTANCE-DATETIME>20101108093628
ACCESSION NUMBER:		0001260768-10-000001
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101029
FILED AS OF DATE:		20101108
DATE AS OF CHANGE:		20101108

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DONOVAN WILLIAM JOSEPH
		CENTRAL INDEX KEY:			0001260768

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-28238
		FILM NUMBER:		101170909

	MAIL ADDRESS:	
		STREET 1:		21351 RIDGETOP CIRCLE
		CITY:			DULLES
		STATE:			VA
		ZIP:			20166

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Applied Visual Sciences, Inc.
		CENTRAL INDEX KEY:			0000873198
		STANDARD INDUSTRIAL CLASSIFICATION:	WHOLESALE-COMPUTER & PERIPHERAL EQUIPMENT & SOFTWARE [5045]
		IRS NUMBER:				541521616
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		250 EXCHANGE PLACE
		STREET 2:		SUITE H
		CITY:			HERNDON
		STATE:			VA
		ZIP:			20170
		BUSINESS PHONE:		703-464-5495

	MAIL ADDRESS:	
		STREET 1:		250 EXCHANGE PLACE
		STREET 2:		SUITE H
		CITY:			HERNDON
		STATE:			VA
		ZIP:			20170

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GUARDIAN TECHNOLOGIES INTERNATIONAL INC
		DATE OF NAME CHANGE:	19960403
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-10-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000873198</issuerCik>
        <issuerName>Applied Visual Sciences, Inc.</issuerName>
        <issuerTradingSymbol>APVS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001260768</rptOwnerCik>
            <rptOwnerName>DONOVAN WILLIAM JOSEPH</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>250 EXCHANGE PLACE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE H</rptOwnerStreet2>
            <rptOwnerCity>HERNDON</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>20170</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; COO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Rule 144 Restricted Common Stock, par value $0.01</value>
            </securityTitle>
            <transactionDate>
                <value>2010-10-29</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2010-10-29</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value>E</value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>900000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.25</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>910200</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Purchase Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.25</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-10-29</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2010-10-29</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value>E</value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>1600000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.25</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2010-10-29</value>
            </exerciseDate>
            <expirationDate>
                <value>2015-10-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Rule 144 Restricted Common Stock, par value $0.01</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1600000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3755772</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <ownerSignature>
        <signatureName>William J Donovan</signatureName>
        <signatureDate>2010-11-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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