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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 SeTbqcrvCxy4z2Zm956dqq5LQvBCFzoayooB3CjJc3JCqvwgOqUsqrL7RDTC6K11
 tle4efY3YfDrrgS8410i1Q==

<SEC-DOCUMENT>0001144204-05-013012.txt : 20050427
<SEC-HEADER>0001144204-05-013012.hdr.sgml : 20050427
<ACCEPTANCE-DATETIME>20050427181055
ACCESSION NUMBER:		0001144204-05-013012
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050425
FILED AS OF DATE:		20050427
DATE AS OF CHANGE:		20050427

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			STONE RICHARD B
		CENTRAL INDEX KEY:			0001063028

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-13835
		FILM NUMBER:		05777673

	BUSINESS ADDRESS:	
		STREET 1:		C/O SUNRISE SECURITIES
		STREET 2:		135 EAST 57TH STREET 11TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	MAIL ADDRESS:	
		STREET 1:		SUNRISE SECURITIES
		STREET 2:		641 LEXINGTON AVE 25TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			APPLIED NEUROSOLUTIONS INC
		CENTRAL INDEX KEY:			0000872947
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				391661164
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		50 LAKEVIEW PARKWAY S
		STREET 2:		STE 111
		CITY:			VERNON HILLS
		STATE:			IL
		ZIP:			60061
		BUSINESS PHONE:		847 573 8000

	MAIL ADDRESS:	
		STREET 1:		50 LAKEVIEW PARKWAY
		STREET 2:		STE 111
		CITY:			VERNON HILLS
		STATE:			IL
		ZIP:			60061

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HEMOXYMED INC
		DATE OF NAME CHANGE:	20020820

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OPHIDIAN PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970714
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v017065_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-04-25</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000872947</issuerCik>
        <issuerName>APPLIED NEUROSOLUTIONS INC</issuerName>
        <issuerTradingSymbol>APNS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001063028</rptOwnerCik>
            <rptOwnerName>STONE RICHARD B</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>50 LAKEVIEW PARKWAY, SUITE 111</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>VERNON HILLS,</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60061</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.285</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-04-25</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>200000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-04-25</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>200000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>200000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Grant under Issuer's 2003 Stock Option Plan.</footnote>
        <footnote id="F2">The options are exercisable as follows:  50,000 options are exercisable on April 25, 2005, and 50,000 options will become
 exercisable on each of April 25, 2006, April 25, 2007 and April 25, 2008.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Richard B. Stone</signatureName>
        <signatureDate>2005-04-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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