X0202 4/A 2006-08-29 2005-09-20 0 0000872947 APPLIED NEUROSOLUTIONS INC APNS 0001374852 Hoffing Ellen Randi 50 LAKEVIEW PARKWAY, SUITE 111 VERNON HILLS IL 60061 1 1 0 0 President & CEO Restricted Common Stock 2006-08-29 4 A 0 400000 0 A 400000 D Stock Option 0.23 2006-08-29 4 A 0 6000000 0 A 2016-08-29 Common Stock 6000000 6000000 D Grant pursuant to the terms of the reporting person's employment with the issuer. The grant of these options was made outside of the Issuer's 2003 Stock Option Plan. The options are exercisable as follows: 1,000,000 options will become exercisable on February 29, 2007, 166,667 options will become exercisable each month thereafter through July 29, 2009 and 166,657 options will become exercisable on August 29, 2009. Grant of restricted shares of common stock pursuant to the terms of the reporting person's employment with the issuer. The restricted shares of common stock vests as follows: 133,334 shares of restricted common stock vests on August 29, 2007, 133,333 shares of restricted common stock vests on August 29, 2008, and 133,333 shares of restricted common stock vests on August 29, 2009 /s/ Ellen R. Hoffing 2006-12-18