X0202 4/A 2006-06-27 2006-06-28 0 0000872947 APPLIED NEUROSOLUTIONS INC APNS 0001200883 VATERS ROBERT S 50 LAKEVIEW PARKWAY SUITE 111 VERNON HILLS IL 60061 1 0 0 0 Stock Option 0.2 2006-06-27 4 A 0 4000000 0.0 A 2016-06-27 Common Stock 4000000 4000000 D Grant approved by the Board of Directors in consideration for the engagement of the reporting person as the Chairman of the issuer. The grant of these options was made outside of the Issuer's 2003 Stock Option Plan. The options are exercisable as follows: 1,000,000 options are exercisable immediately, 1,000,000 options will become exercisable on December 27, 2006, 666,667 options will become exercisable on June 27, 2008 and 666,666 options will become exercisable on June 27, 2009. /s/ Robert S. Vaters 2005-12-18