SCHEDULE 13G/A 0001930214 XXXXXXXX LIVE 2 Common Stock, $0.01 par value per share 03/31/2025 0000872912 Delcath Systems, Inc. 24661P807 566 Queensbury Avenue, Queensbury, NY 12804 Rule 13d-1(c) Vivo Opportunity Fund Holdings, L.P. b DE 750195.00 0.00 750195.00 0.00 750195.00 N 2.2 PN (1) The number represents shares of common stock, par value $0.01 per share (the "Common Stock") of Delcath Systems, Inc. (the "Issuer") held of record by Vivo Opportunity Fund Holdings, L.P. as of March 31, 2025. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. (2) Based on 34,826,183 shares of Common Stock outstanding as of May 6, 2025, as disclosed in the Issuer's Quarterly Report on Form 10-Q, filed with the Securities and Exchange Commission (the "SEC") on May 8, 2025. Vivo Opportunity, LLC b DE 750195.00 0.00 750195.00 0.00 750195.00 N 2.2 OO (1) The number represents shares of Common Stock of the Issuer held of record by Vivo Opportunity Fund Holdings, L.P. as of March 31, 2025. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. (2) Based on 34,826,183 shares of Common Stock outstanding as of May 6, 2025, as disclosed in the Issuer's Quarterly Report on Form 10-Q, filed with the SEC on May 8, 2025. Delcath Systems, Inc. 566 Queensbury Avenue, Queensbury, NY 12804 (i) Vivo Opportunity Fund Holdings, L.P., a Delaware limited partnership; and (ii) Vivo Opportunity, LLC, a Delaware limited liability company. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P. 192 Lytton Avenue, Palo Alto, CA 94301. Y The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4. The information set forth in rows 5 through 11 of the cover pages is incorporated by reference into this Item 4. Vivo Opportunity Fund Holdings, L.P.: 750,195 Vivo Opportunity, LLC: 750,195 Vivo Opportunity Fund Holdings, L.P.: 0 Vivo Opportunity, LLC: 0 Vivo Opportunity Fund Holdings, L.P.: 750,195 Vivo Opportunity, LLC: 750,195 Vivo Opportunity Fund Holdings, L.P.: 0 Vivo Opportunity, LLC: 0 Percentage of Common Stock Outstanding Vivo Opportunity Fund Holdings, L.P.: 2.2% Vivo Opportunity, LLC: 2.2% N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Vivo Opportunity Fund Holdings, L.P. /s/ Kevin Dai 05/14/2025 Vivo Opportunity, LLC /s/ Kevin Dai 05/14/2025