NPORT-P false 0000872625 XXXXXXXX S000006882 C000018631 C000081539 C000128862 C000141458 Franklin Strategic Series 811-06243 0000872625 549300NDWC0J6DXVSX36 One Franklin Parkway San Mateo 94403-1906 650-312-2000 Franklin Biotechnology Discovery Fund S000006882 6N5133EDK315FXQQM036 2027-04-30 2026-07-31 N 1192074830.96 37827946.59 1154246884.37 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 310802.11000000 N Abivax SA 969500D8TMNB184OJU95 00370M103 109022.00000000 NS USD 13619028.24000000 1.179905999697 Long EC CORP FR N 1 N N N Achieve Life Sciences, Inc. 549300V82ZKZDTAU0A46 004468500 1095791.00000000 NS USD 7034978.22000000 0.609486437889 Long EC CORP US N 1 N N Acumen Pharmaceuticals, Inc. N/A 00509G209 826400.00000000 NS USD 1776760.00000000 0.153932405974 Long EC CORP US N 1 N N N Adicet Bio, Inc. 549300VRD2QO80WBOP18 007002207 225186.00000000 NS USD 2051444.46000000 0.177730127564 Long EC CORP US N 1 N N N Spyre Therapeutics, Inc. 52990017AIJPRH3HQH40 00773J202 25009.00000000 NS USD 2459134.97000000 0.213051038153 Long EC CORP US N 1 N N N Jade Biosciences, Inc. N/A 008064206 479949.00000000 NS USD 9478992.75000000 0.821227492866 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals, Inc. 529900S3ZI14OWRJII50 02043Q107 51286.00000000 NS USD 10540298.72000000 0.913175410107 Long EC CORP US N 1 N N N Alto Neuroscience, Inc. N/A 02157Q109 182834.00000000 NS USD 4949316.38000000 0.428791833620 Long EC CORP US N 1 N N N Amgen, Inc. 62QBXGPJ34PQ72Z12S66 031162100 131554.00000000 NS USD 50669338.64000000 4.389818099241 Long EC CORP US N 1 N N N Amylyx Pharmaceuticals, Inc. N/A 03237H101 752824.00000000 NS USD 15289855.44000000 1.324660750403 Long EC CORP US N 1 N N N Arcutis Biotherapeutics, Inc. N/A 03969K108 505651.00000000 NS USD 13581785.86000000 1.176679447344 Long EC CORP US N 1 N N N Argenx SE 7245009C5FZE6G9ODQ71 04016X101 48962.00000000 NS USD 41804734.84000000 3.621819162441 Long EC CORP NL N 1 N N N Artiva Biotherapeutics, Inc. N/A 04317A107 542371.00000000 NS USD 5477947.10000000 0.474590590122 Long EC CORP US N 1 N N Assembly Biosciences, Inc. 5299007Y1X8RBDFT8C40 045396207 40982.00000000 NS USD 1029058.02000000 0.089154065212 Long EC CORP US N 1 N N Aura Biosciences, Inc. N/A 05153U107 765617.00000000 NS USD 5366975.17000000 0.464976361875 Long EC CORP US N 1 N N Avalo Therapeutics, Inc. 549300GPK6FPJ3X8SZ39 05338F306 147877.00000000 NS USD 2698755.25000000 0.233810919184 Long EC CORP US N 1 N N N Avalyn Pharma, Inc. N/A 05348Y105 120364.00000000 NS USD 3465279.56000000 0.300219962204 Long EC CORP US N 1 N N Bicara Therapeutics, Inc. N/A 055477103 474899.00000000 NS USD 12869762.90000000 1.114992214774 Long EC CORP US N 1 N N N BeOne Medicines Ltd. 549300JFUK6FRD5MH739 07725L102 33421.00000000 NS USD 10561370.21000000 0.915000971890 Long EC CORP CH N 1 N N N Benitec Biopharma, Inc. N/A 08205P209 995152.00000000 NS USD 11653229.92000000 1.009595960604 Long EC CORP US N 1 N N N BioNTech SE 894500UZJ5LG1F8J1U58 09075V102 73400.00000000 NS USD 6648572.00000000 0.576009525347 Long EC CORP DE N 1 N N N BioAge Labs, Inc. 529900NG0C40250Z7875 09077V100 135049.00000000 NS USD 1220842.96000000 0.105769656087 Long EC CORP US N 1 N N N Sanofi SA N/A N/A 2333755.00000000 NS USD 2.33000000 0.000000201863 Long EC CORP CO N 3 N N N Bridgebio Pharma, Inc. 54930028YG89VTY2J114 10806X102 241119.00000000 NS USD 19311220.71000000 1.673058075486 Long EC CORP US N 1 N N N Cabaletta Bio, Inc. N/A 12674W109 876846.00000000 NS USD 2349947.28000000 0.203591390353 Long EC CORP US N 1 N N Cardiff Oncology, Inc. 549300AHOLZBHHYFWP04 14147L108 438961.00000000 NS USD 375487.24000000 0.032530929481 Long EC CORP US N 1 N N Celcuity, Inc. 25490070W7UU7W2SEY87 15102K100 46107.00000000 NS USD 3982722.66000000 0.345049461595 Long EC CORP US N 1 N N N CG oncology, Inc. N/A 156944100 174532.00000000 NS USD 12424933.08000000 1.076453681465 Long EC CORP US N 1 N N N Cogent Biosciences, Inc. N/A 19240Q201 75829.00000000 NS USD 2952022.97000000 0.255753167712 Long EC CORP US N 1 N N N Context Therapeutics, Inc. N/A 21077P108 1398833.00000000 NS USD 838460.50000000 0.072641348341 Long EC CORP US N 1 N N N Contineum Therapeutics, Inc. N/A 21217B100 330090.00000000 NS USD 5113094.10000000 0.442980974801 Long EC CORP US N 1 N N N Cytokinetics, Inc. 549300BE5DY1HW7IHA64 23282W605 186018.00000000 NS USD 14347568.34000000 1.243024220752 Long EC CORP US N 1 N N N Definium Therapeutics, Inc. 549300QY8KN1O6RPFJ13 24477V105 86980.00000000 NS USD 3785369.60000000 0.327951467858 Long EC CORP CA N 1 N N N Dianthus Therapeutics, Inc. 549300Z3N6ODPCOFC890 252828108 250308.00000000 NS USD 26762931.36000000 2.318648784970 Long EC CORP US N 1 N N N Dyne Therapeutics, Inc. N/A 26818M108 519232.00000000 NS USD 13074261.76000000 1.132709296168 Long EC CORP US N 1 N N N Eikon Therapeutics, Inc. N/A 282564103 127376.00000000 NS USD 1173132.96000000 0.101636224960 Long EC CORP US N 1 N N EyePoint, Inc. 549300QE1RU34T50MR69 30233G209 1123495.00000000 NS USD 13762813.75000000 1.192363084221 Long EC CORP US N 1 N N N Gilead Sciences, Inc. 549300WTZWR07K8MNV44 375558103 341817.00000000 NS USD 44507991.57000000 3.856020074448 Long EC CORP US N 1 N N N GRAIL, Inc. 2549009XSNESW3VE8024 384747101 46433.00000000 NS USD 3183446.48000000 0.275802908641 Long EC CORP US N 1 N N N Guardant Health, Inc. 254900M8C3E5VC8BR186 40131M109 196520.00000000 NS USD 31834274.80000000 2.758012625468 Long EC CORP US N 1 N N N Ideaya Biosciences, Inc. 549300ULW08F62IJML11 45166A102 81852.00000000 NS USD 2905746.00000000 0.251743889400 Long EC CORP US N 1 N N N Immix Biopharma, Inc. N/A 45258H106 357034.00000000 NS USD 2970522.88000000 0.257355936604 Long EC CORP US N 1 N N Indivior Pharmaceuticals, Inc. 254900MKFFZZSS7N1I14 45579U109 332496.00000000 NS USD 13303164.96000000 1.152540686064 Long EC CORP US N 1 N N N IN8bio, Inc. 549300H68IVCRKSGSL94 45674E208 332083.00000000 NS USD 345366.32000000 0.029921356052 Long EC CORP US N 1 N N N Insmed, Inc. 529900Q55QAG41CCAC11 457669307 233052.00000000 NS USD 22978927.20000000 1.990815614160 Long EC CORP US N 1 N N N Franklin Institutional U.S. Government Money Market Fund 549300M4TP89K77LG374 457756500 16697192.88000000 NS USD 16697192.88000000 1.446587650016 Long STIV RF US N 1 N N N Inventiva SACA 969500I9Y690B3FZW590 46124U107 1014919.00000000 NS USD 4546837.12000000 0.393922407898 Long EC CORP FR N 1 N N Ionis Pharmaceuticals, Inc. 549300SI4ZGLG0BLUZ92 462222100 209423.00000000 NS USD 10841828.71000000 0.939298936545 Long EC CORP US N 1 N N N Kailera Therapeutics, Inc. N/A 482931102 146385.00000000 NS USD 2479761.90000000 0.214838084778 Long EC CORP US N 1 N N Kardigan, Inc. N/A 485925101 144820.00000000 NS USD 3015152.40000000 0.261222485486 Long EC CORP US N 1 N N Krystal Biotech, Inc. 549300YONUY68210OE41 501147102 14607.00000000 NS USD 4982739.84000000 0.431687527813 Long EC CORP US N 1 N N N Eli Lilly & Co. FRDRIPF3EKNDJ2CQJL29 532457108 13131.00000000 NS USD 15085418.04000000 1.306948993692 Long EC CORP US N 1 N N N MBX Biosciences, Inc. N/A 55287L101 85528.00000000 NS USD 5638861.04000000 0.488531623204 Long EC CORP US N 1 N N N Sartorius AG 529900EQV2DY4FOAMU38 N/A 9200.00000000 NS 2318711.84000000 0.200885258725 Long EP CORP DE N 2 N N N Mineralys Therapeutics, Inc. N/A 603170101 533511.00000000 NS USD 13615200.72000000 1.179574396462 Long EC CORP US N 1 N N N Mirum Pharmaceuticals, Inc. 254900YZKR40F7F27K81 604749101 215190.00000000 NS USD 22799380.50000000 1.975260302517 Long EC CORP US N 1 N N N Neurocrine Biosciences, Inc. 549300FECER0XBN49756 64125C109 125643.00000000 NS USD 20957252.40000000 1.815664628060 Long EC CORP US N 1 N N N Neurogene, Inc. 529900A7VIY892SZVW73 64135M105 218783.00000000 NS USD 7195772.87000000 0.623417136094 Long EC CORP US N 1 N N N Odyssey Therapeutics, Inc. N/A 67613T104 99826.00000000 NS USD 1889706.18000000 0.163717676485 Long EC CORP US N 1 N N Olema Pharmaceuticals, Inc. N/A 68062P106 568915.00000000 NS USD 6514076.75000000 0.564357317157 Long EC CORP US N 1 N N N ORIC Pharmaceuticals, Inc. 54930033FJRNEYBW0L25 68622P109 659005.00000000 NS USD 7295185.35000000 0.632029893152 Long EC CORP US N 1 N N N Oruka Therapeutics, Inc. 529900TG7O4ESUDMGI54 687604108 73869.00000000 NS USD 7129097.19000000 0.617640583356 Long EC CORP US N 1 N N N PTC Therapeutics, Inc. 549300UJLWOIWFDGB318 69366J200 279737.00000000 NS USD 19024913.37000000 1.648253387349 Long EC CORP US N 1 N N N Palisade Bio, Inc. 549300W6LIDX3I5XXT34 696389154 1447549.00000000 NS USD 2742960.60000000 0.237640719428 Long CORP US N 3 N N N Palisade Bio, Inc. 549300W6LIDX3I5XXT34 696389402 2119910.00000000 NS USD 4017229.45000000 0.348039011791 Long EC CORP US N 1 N N N Parabilis Medicines, Inc. N/A 698955101 93010.00000000 NS USD 3160479.80000000 0.273813154083 Long EC CORP US N 1 N N Phathom Pharmaceuticals, Inc. N/A 71722W107 507425.00000000 NS USD 4439968.75000000 0.384663698046 Long EC CORP US N 1 N N N Praxis Precision Medicines, Inc. N/A 74006W207 71799.00000000 NS USD 22101886.17000000 1.914831780729 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals, Inc. 549300RCBFWIRX3HYQ56 75886F107 57013.00000000 NS USD 43479824.19000000 3.766943171237 Long EC CORP US N 1 N N N Relay Therapeutics, Inc. N/A 75943R102 404940.00000000 NS USD 7625020.20000000 0.660605655796 Long EC CORP US N 1 N N N Relmada Therapeutics, Inc. 549300217EASRZ9JSF81 75955J402 788718.00000000 NS USD 4188092.58000000 0.362842008647 Long EC CORP US N 1 N N N Revolution Medicines, Inc. 549300JU3X0LBCQ65892 76155X100 185428.00000000 NS USD 34773312.84000000 3.012640823282 Long EC CORP US N 1 N N N Benitec Biopharma, Inc. N/A N/A 310881.00000000 NS USD 3640385.42000000 0.315390534667 Long EC CORP US N 3 N N N Satellos Bioscience, Inc. 529900EN243BZ5QC9N39 80401L803 246407.00000000 NS USD 2461605.93000000 0.213265113671 Long EC CORP CA N 1 N N N Scribe Therapeutics, Inc. N/A 811033109 135567.00000000 NS USD 2640845.16000000 0.228793787166 Long EC CORP US N 1 N N Faeth Therapeutics, Inc. 8945002MP2CXKAENWU30 81728A207 180711.00000000 NS USD 4922567.64000000 0.426474414326 Long EC CORP US N 1 N N Sionna Therapeutics, Inc. N/A 829401108 107956.00000000 NS USD 5087966.28000000 0.440803986469 Long EC CORP US N 1 N N Solid Biosciences, Inc. N/A 83422E204 1409093.00000000 NS USD 11357289.58000000 0.983956702313 Long EC CORP US N 1 N N N SpyGlass Pharma, Inc. N/A 85220G109 84708.00000000 NS USD 1908471.24000000 0.165343417066 Long EC CORP US N 1 N N Structure Therapeutics, Inc. N/A 86366E106 101791.00000000 NS USD 4890039.64000000 0.423656299723 Long EC CORP KY N 1 N N N Syndax Pharmaceuticals, Inc. 529900OF94TRHKZVBS87 87164F105 582815.00000000 NS USD 11102625.75000000 0.961893499592 Long EC CORP US N 1 N N N Tango Therapeutics, Inc. N/A 87583X109 521761.00000000 NS USD 14181463.98000000 1.228633507444 Long EC CORP US N 1 N N N Thermo Fisher Scientific, Inc. HCHV7422L5HDJZCRFL38 883556102 22999.00000000 NS USD 13208325.70000000 1.144324137137 Long EC CORP US N 1 N N N Tyra Biosciences, Inc. N/A 90240B106 62752.00000000 NS USD 2000533.76000000 0.173319398743 Long EC CORP US N 1 N N N Ultragenyx Pharmaceutical, Inc. 529900EV44GVDN1DCX77 90400D108 108067.00000000 NS USD 2691948.97000000 0.233221246377 Long EC CORP US N 1 N N N Vaxcyte, Inc. 254900M7NMHTGASX8D95 92243G108 145674.00000000 NS USD 7878049.92000000 0.682527284819 Long EC CORP US N 1 N N N VeraDermics, Inc. N/A 922967104 31081.00000000 NS USD 3263505.00000000 0.282738904838 Long EC CORP US N 1 N N Verastem, Inc. 549300IY0EFBIU8NQC81 92337C203 401744.00000000 NS USD 2330115.20000000 0.201873206811 Long EC CORP US N 1 N N N Vertex Pharmaceuticals, Inc. 54930015RAQRRZ5ZGJ91 92532F100 85620.00000000 NS USD 40849302.00000000 3.539043730864 Long EC CORP US N 1 N N N Vor BioPharma, Inc. N/A 929033207 148745.00000000 NS USD 3145956.75000000 0.272554926731 Long EC CORP US N 1 N N N Xenon Pharmaceuticals, Inc. 549300XV44Q9Z1MIPQ03 98420N105 123767.00000000 NS USD 7756477.89000000 0.671994700183 Long EC CORP CA N 1 N N N IN8bio, Inc. 549300H68IVCRKSGSL94 N/A 69673.00000000 NS USD 4.46000000 0.000000386399 Long CORP US Y 3 N N N Achieve Life Sciences, Inc. 549300V82ZKZDTAU0A46 N/A 698900.00000000 NS USD 2390238.00000000 0.207082040451 Long CORP US N 3 N N N Assembly Biosciences, Inc. 5299007Y1X8RBDFT8C40 N/A 44450.00000000 NS USD 445381.53000000 0.038586331575 Long EC CORP US N 3 N N N Assembly Biosciences, Inc. 5299007Y1X8RBDFT8C40 N/A 44450.00000000 NS USD 22556.37000000 0.001954206704 Long EC CORP US N 3 N N N Acumen Pharmaceuticals, Inc. N/A N/A 223305.00000000 NS USD 480105.75000000 0.041594719162 Long EC CORP US Y 2 N N N Obsidian Therapeutics, Inc. N/A N/A 4354.00000000 NS USD 6385654.25000000 0.553231231244 Long EC CORP US N 3 N N N Ray Therapeutics, Inc. N/A N/A 1389029.00000000 NS USD 3784235.88000000 0.327853246237 Long EC CORP US Y 3 N N N Achieve Life Sciences, Inc. 549300V82ZKZDTAU0A46 N/A 706649.00000000 NS USD 4536686.58000000 0.393042999849 Long EC CORP US Y 3 N N N Achieve Life Sciences, Inc. 549300V82ZKZDTAU0A46 N/A 706649.00000000 NS USD 2056348.59000000 0.178155004604 Long CORP US Y 3 N N N Lycia Therapeutics, Inc. N/A N/A 177052.00000000 NS USD 426799.25000000 0.036976426428 Long EP CORP US Y 3 N N N Baylor College of Medicine 5493006UKJHZXSM3H989 N/A 188069.00000000 NS USD 3433011.71000000 0.297424386107 Long EP CORP US N 3 N N N Processa Pharmaceuticals, Inc. 529900A51HZIE4XJB960 N/A 2862.00000000 NS USD 5513145.75000000 0.477640080701 Long EP CORP US Y 3 N N N Oruka Therapeutics, Inc. 529900TG7O4ESUDMGI54 687604108 222393.00000000 NS USD 21463148.43000000 1.859493728823 Long EC CORP US N 1 N N N Contineum Therapeutics, Inc. N/A 21217B100 295058.00000000 NS USD 4570448.42000000 0.395968010127 Long EC CORP US N 1 N N N Spyre Therapeutics, Inc. 52990017AIJPRH3HQH40 00773J202 220000.00000000 NS USD 21632600.00000000 1.874174432951 Long EC CORP US N 1 N N N Structure Therapeutics, Inc. N/A 86366E106 34633.00000000 NS USD 1663769.32000000 0.144143280136 Long EC CORP KY N 1 N N N Alto Neuroscience, Inc. N/A 02157Q109 165070.00000000 NS USD 4468444.90000000 0.387130774231 Long EC CORP US N 1 N N N Vicore Pharma Holding AB 549300KTNBPTZLF01130 92581R104 130759.00000000 NS USD 1427888.28000000 0.123707354062 Long EC CORP SE N 1 N N Satellos Bioscience, Inc. 529900EN243BZ5QC9N39 80401L803 96830.00000000 NS 967022.15000000 0.083779489734 Long EC CORP CA N 1 N N N Vicore Pharma Holding AB 549300KTNBPTZLF01130 N/A 8.00000000 NS 9.33000000 0.000000808319 Long EC CORP SE N 2 N N N Sartorius Stedim Biotech 52990006IVXY7GCSSR39 N/A 10100.00000000 NS 1952735.01000000 0.169178278619 Long EC CORP FR N 2 N N N Danish Krone N/A N/A 739.99000000 OU Currencies 114.16000000 0.000009890431 Long STIV DK N 1 N N N Franklin Institutional U.S. Government Money Market Fund 549300M4TP89K77LG374 457756500 36651413.05000000 NS USD 36651413.05000000 3.175352998245 Long STIV RF US N 1 N N Alkermes plc N/A N/A 232937.00000000 NS USD 11411583.63000000 0.988660553000 Long EC CORP IE N 1 N N N AstraZeneca plc PY6ZZQWO2IZFZC3IOL08 N/A 102531.00000000 NS USD 17393358.84000000 1.506901086373 Long EC CORP GB N 1 N N N JATT II Acquisition Corp. N/A N/A 146753.00000000 NS USD 1775711.30000000 0.153841550195 Long EC CORP KY N 1 N N N Jazz Pharmaceuticals plc 635400GAUMJCLEZRRV50 N/A 258371.00000000 NS USD 65331691.06000000 5.660114135431 Long EC CORP IE N 1 N N N Oculis Holding AG 5067005370C2KK324336 N/A 314736.00000000 NS USD 3559664.16000000 0.308397120945 Long EC CORP CH N 1 N N Ascendis Pharma A/S 549300B66JN3W3J8GH73 N/A 121287.00000000 NS USD 29583112.17000000 2.562979599130 Long EC CORP DK N 1 N N N InflaRx NV 391200708PAUDLQ31581 N/A 376105.00000000 NS USD 639378.50000000 0.055393565159 Long EC CORP NL N 1 N N Newamsterdam Pharma Co. NV 984500B6549TF6E14D36 N/A 187726.00000000 NS USD 5216905.54000000 0.451974842699 Long EC CORP NL N 1 N N N uniQure NV 724500RPCTZLFYJZ3S98 N/A 88716.00000000 NS USD 3870679.08000000 0.335342389259 Long EC CORP NL N 1 N N N Carmot Therapeutics, Inc. N/A N/A 83100.00000000 NS USD 305253.72000000 0.026446137662 Long EC CORP US N 3 N N N Lycia LLC N/A N/A 859370.00000000 NS USD 2071586.15000000 0.179475134657 Long EC CORP JP Y 3 N N N Candid, Inc. N/A N/A 1519609.00000000 NS USD 5563712.52000000 0.482021012604 Long EC CORP US Y 3 N N N 2026-08-31 Franklin Strategic Series Monica Krogh Monica Krogh Assistant Treasurer XXXX