2
a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
98.7%
Biotechnology
78.2%
a
89bio,
Inc.
...........................................
United
States
284,400
$
4,453,704
a
ACADIA
Pharmaceuticals,
Inc.
...........................
United
States
294,600
6,372,198
a
Acceleron
Pharma,
Inc.
.................................
United
States
142,114
17,772,777
a
Acumen
Pharmaceuticals,
Inc.
...........................
United
States
336,100
5,202,828
a
Akouos
,
Inc.
.........................................
United
States
157,600
1,713,112
a
Albireo
Pharma,
Inc.
...................................
United
States
102,400
2,929,664
a
Alector
,
Inc.
..........................................
United
States
677,446
16,282,415
a
ALX
Oncology
Holdings,
Inc.
.............................
United
States
86,100
5,042,016
Amgen,
Inc.
.........................................
United
States
318,700
76,978,798
a,b
Applied
Molecular
Transport,
Inc.
.........................
United
States
138,000
3,868,140
a
Applied
Therapeutics,
Inc.
...............................
United
States
311,757
5,365,338
a
Arcus
Biosciences,
Inc.
.................................
United
States
519,014
16,302,230
a
Arcutis
Biotherapeutics
,
Inc.
.............................
United
States
125,200
2,920,916
a
Argenx
SE,
ADR
......................................
Netherlands
51,298
15,616,650
a
Ascendis
Pharma
A/S,
ADR
.............................
Denmark
222,800
26,332,732
a
Biogen,
Inc.
.........................................
United
States
148,175
48,413,218
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
142,456
10,930,649
a
Blueprint
Medicines
Corp.
...............................
United
States
117,200
10,298,364
a
Bridgebio
Pharma,
Inc.
.................................
United
States
118,800
6,349,860
a
Candel
Therapeutics,
Inc.
...............................
United
States
400,800
3,042,072
a,c,d
Centessa
Pharmaceuticals
plc
...........................
United
States
189,737
3,720,081
a
Centessa
Pharmaceuticals
plc,
ADR
.......................
United
States
71,600
1,477,824
a
Codiak
Biosciences,
Inc.
................................
United
States
252,600
4,369,980
a
CRISPR
Therapeutics
AG
...............................
Switzerland
130,614
15,806,906
a
Cullinan
Oncology,
Inc.
.................................
United
States
113,700
2,607,141
a
Cytokinetics,
Inc.
......................................
United
States
254,100
7,541,688
a,c,d
Day
One
Biopharmaceuticals,
Inc.
.........................
United
States
370,698
8,131,794
a
Deciphera
Pharmaceuticals,
Inc.
..........................
United
States
678,554
20,689,111
a
Dyne
Therapeutics,
Inc.
................................
United
States
215,539
3,894,790
a,b
Equillium
,
Inc.
........................................
United
States
294,800
1,597,816
a
Fate
Therapeutics,
Inc.
.................................
United
States
242,110
20,046,708
a,b
Forte
Biosciences,
Inc.
.................................
United
States
279,964
8,387,721
a
Gemini
Therapeutics,
Inc.
...............................
United
States
576,689
2,347,124
Gilead
Sciences,
Inc.
..................................
United
States
893,078
60,988,297
a
Global
Blood
Therapeutics,
Inc.
...........................
United
States
391,500
10,699,695
a
Harpoon
Therapeutics,
Inc.
..............................
United
States
220,200
2,155,758
a
Heron
Therapeutics,
Inc.
................................
United
States
1,739,677
21,502,408
a
Horizon
Therapeutics
plc
................................
United
States
488,349
48,844,667
a
Insmed
,
Inc.
.........................................
United
States
906,600
22,302,360
a,c,d
Intarcia
Therapeutics,
Inc.,
DD
...........................
United
States
80,195
—
a
Intellia
Therapeutics,
Inc.
................................
United
States
121,053
17,171,368
a
Iovance
Biotherapeutics
,
Inc.
.............................
United
States
1,395,901
31,086,715
a
KalVista
Pharmaceuticals,
Inc.
...........................
United
States
366,100
7,373,254
a
Karuna
Therapeutics,
Inc.
...............................
United
States
42,300
4,831,506
a
Keros
Therapeutics,
Inc.
................................
United
States
148,751
5,474,037
a
Kezar
Life
Sciences,
Inc.
................................
United
States
853,550
4,156,788
a,b
Kinnate
Biopharma,
Inc.
................................
United
States
19,606
423,097
a
Kodiak
Sciences,
Inc.
..................................
United
States
77,300
6,480,832
a,b
Kronos
Bio,
Inc.
......................................
United
States
167,371
3,422,737
a
Krystal
Biotech,
Inc.
...................................
United
States
52,100
3,044,724
a
Kura
Oncology,
Inc.
....................................
United
States
132,400
2,507,656
a
Legend
Biotech
Corp.,
ADR
.............................
United
States
207,725
8,938,407
a,b
LogicBio
Therapeutics,
Inc.
..............................
United
States
661,200
2,757,204
a
Merus
NV
...........................................
Netherlands
73,200
1,259,040
a
Metacrine
,
Inc.
.......................................
United
States
512,819
1,446,150
a
Mirati
Therapeutics,
Inc.
................................
United
States
243,619
38,993,657
a
Moderna
,
Inc.
........................................
United
States
114,200
40,381,120
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
215,800
20,114,718