X0306 4 2022-12-09 0 0000872589 REGENERON PHARMACEUTICALS, INC. REGN 0001013064 VAGELOS P ROY 777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591 1 0 0 0 Common Stock 2022-05-24 5 G 0 23077 0.0 D 322489 D Common Stock 2022-12-09 4 F 0 57 753.28 D 322432 D Common Stock 2022-04-06 5 G 0 302 0.0 D 126704 I by CLAT Common Stock 2022-07-05 5 G 0 357 0.0 D 126347 I by CLAT Common Stock 2022-10-03 5 G 0 304 0.0 D 126043 I by CLAT Common Stock 2102 I By 401(k) Plan Common Stock 23461 I by Spouse as Trustee Common Stock 3609 I by trust for grandch Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). By trusts for the benefit of nine grandchildren of the reporting person, each of which holds 401 shares of Company stock. The reporting person and/or the spouse of the reporting person is the trustee of each such trust. /s/**P. Roy Vagelos 2022-12-11