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Insider Trading Arrangements
 3 Months Ended 9 Months Ended
Sep. 30, 2023
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Sep. 30, 2023
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Trading Arrangements, by Individual    
Material Terms of Trading Arrangement  
As disclosed in the table below, during the three months ended September 30, 2023, certain of our directors and/or executive officers adopted plans for trading arrangements intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) of the Exchange Act.
NamePositionDate of Plan Adoption
Scheduled End Date of Trading Arrangement(a)
Total Number of Securities to Be Sold Under the Plan
Michael S. Brown, M.D.
Director
8/24/20235/24/20242,049 
Christopher Fenimore
Senior Vice President, Controller
8/25/20232/15/20248,940 
Joseph L. Goldstein, M.D.
Director
8/24/20235/24/20243,537 
Arthur F. Ryan
Director
8/7/202311/29/20241,200 
(a) In each case, the trading arrangement may expire on an earlier date if and when all transactions under the arrangement are completed.
Non-Rule 10b5-1 Arrangement Adopted false  
Rule 10b5-1 Arrangement Terminated false  
Non-Rule 10b5-1 Arrangement Terminated false  
Michael S. Brown, M.D. [Member]    
Trading Arrangements, by Individual    
Name Michael S. Brown, M.D.  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 8/24/2023  
Arrangement Duration 274 days  
Aggregate Available 2,049 2,049
Christopher R. Fenimore [Member]    
Trading Arrangements, by Individual    
Name Christopher Fenimore  
Title Senior Vice President, Controller  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 8/25/2023  
Arrangement Duration 174 days  
Aggregate Available 8,940 8,940
Joseph L. Goldstein, M.D. [Member]    
Trading Arrangements, by Individual    
Name Joseph L. Goldstein, M.D.  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 8/24/2023  
Arrangement Duration 274 days  
Aggregate Available 3,537 3,537
Arthur F. Ryan [Member]    
Trading Arrangements, by Individual    
Name Arthur F. Ryan  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 8/7/2023  
Arrangement Duration 480 days  
Aggregate Available 1,200 1,200