Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Accrued payroll and related costs	$ 440.7	$ 465.8
Accrued clinical expenses	295.8	283.0
Accrued sales-related costs	472.7	423.9
Income taxes payable	326.3	19.5
Amounts due to collaborators (see Note 3)	287.4	16.1
Other accrued expenses and liabilities	383.9	435.9
Accrued expenses and other current liabilities	$ 2,206.8	$ 1,644.2