X0306 4 2018-07-09 0 0000872589 REGENERON PHARMACEUTICALS INC REGN 0001013064 VAGELOS P ROY 777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591 1 1 0 0 Chairman of the Board Common Stock 2018-07-09 4 M 0 153274 16.8 A 553121 D Common Stock 2018-07-09 4 F 0 78604 370.52 D 474517 D Common Stock 2018-07-10 4 S 0 900 364.75 D 473617 D Common Stock 2018-07-10 4 S 0 17221 365.56 D 456396 D Common Stock 2018-07-10 4 S 0 24339 366.49 D 432057 D Common Stock 2018-07-10 4 S 0 6405 367.4 D 425652 D Common Stock 2018-07-10 4 S 0 12211 368.61 D 413441 D Common Stock 2018-07-10 4 S 0 13194 369.41 D 400247 D Common Stock 2018-07-10 4 S 0 100 370.17 D 400147 D Common Stock 2018-07-10 4 S 0 300 371.29 D 399847 D Common Stock 2018-07-06 5 G 0 610 0.0 D 147934 I by CLAT Common Stock 2310 I By 401(k) Plan Common Stock 83652 I by Spouse as Trustee Common Stock 1203 I by trust for grandch Non-Qualified Stock Option (right to buy) 16.8 2018-07-09 4 M 0 153274 0.0 D 2018-12-17 Common Stock 153274 0 D Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). Represents volume-weighted average price of sales of 900 shares of Company stock on July 10, 2018 at prices ranging from $364.73 to $364.83. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 17,221 shares of Company stock on July 10, 2018 at prices ranging from $365.05 to $365.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 24,339 shares of Company stock on July 10, 2018 at prices ranging from $366.00 to $366.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 6,405 shares of Company stock on July 10, 2018 at prices ranging from $367.02 to $367.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 12,211 shares of Company stock on July 10, 2018 at prices ranging from $368.01 to $368.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 13,194 shares of Company stock on July 10, 2018 at prices ranging from $369.00 to $369.87. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. Represents volume-weighted average price of sales of 300 shares of Company stock on July 10, 2018 at prices ranging from $371.28 to $371.32. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 10, 2018 at each separate price. By a trust for the benefit of certain grandchildren of the reporting person, of which the reporting person and/or the spouse of the reporting person is trustee. The stock option award (combined incentive stock option and non-qualified stock option) vests in four equal annual installments, commencing one year after the date of grant. /s/**P. Roy Vagelos 2018-07-10