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Collaboration Agreements (Bayer HealthCare LLC) (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Mar. 31, 2016
Aug. 31, 2007
Oct. 31, 2006
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Collaboration Agreements [Line Items]            
Accounts receivable from Bayer       $ 242,014 $ 175,263  
Deferred revenue, current portion       320,138 231,664  
Other Collaboration Revenue       938,052 744,270 $ 580,488
Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreement [Abstract]            
Contingent reimbursement obligation       251,000    
Collaboration Agreements [Line Items]            
Deferred Revenue, Additions   $ 20,000 $ 75,000      
Net profit (loss) from commercialization of products under collaboration agreement       802,298 649,232 466,667
Revenue Recognition, Milestone Method, Revenue Recognized       0 0 15,000
Research and Development Arrangement, Contract to Perform for Others, Compensation Earned       13,325 9,010 8,887
Other Collaboration Revenue       874,257 710,769 560,020
Contracts Revenue       58,634 52,527 69,466
EYLEA            
Collaboration Agreements [Line Items]            
Deferred revenue, current portion       68,734 62,373  
Ang2            
Collaboration Agreements [Line Items]            
Deferred revenue, current portion       0 45,739  
Ang2 Antibody [Member]            
Collaboration Agreements [Line Items]            
Deferred Revenue, Additions $ 50,000          
Percentage of global development cost to be paid by the collaboration partner under the collaboration 25.00%          
Percentage of development cost for the territory outside the United States to be paid for under the collaboration 50.00%          
Ang2 antibody and PDGFR-beta antibody            
Collaboration Agreements [Line Items]            
Research and Development Arrangement, Contract to Perform for Others, Compensation Earned       17,841 18,327 10,075
Other Collaboration Revenue       63,795 33,501 20,468
Contracts Revenue       $ 45,954 $ 15,174 $ 10,393
Minimum | Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Revenue based on percentage of annual sales in Japan       33.50%    
Maximum | Collaboration Agreement with Bayer HealthCare LLC            
Collaboration Agreements [Line Items]            
Revenue based on percentage of annual sales in Japan       40.00%