CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Revenues:
Revenue from contract with customer	$ 14,342.9	$ 14,202.0	$ 13,117.2
Expenses:
Research and development	5,850.2	5,132.0	4,439.0
Acquired in-process research and development	124.1	101.0	186.1
Selling, general, and administrative	2,700.0	2,954.4	2,631.3
Other operating (income) expense, net	(10.0)	53.4	(2.1)
Total expenses	10,765.0	10,211.3	9,070.1
Income from operations	3,577.9	3,990.7	4,047.1
Other income (expense):
Other income (expense), net	1,696.6	844.4	225.2
Interest expense	(43.8)	(55.2)	(73.0)
Total other income (expense)	1,652.8	789.2	152.2
Income before income taxes	5,230.7	4,779.9	4,199.3
Income tax expense	725.8	367.3	245.7
Net income	$ 4,504.9	$ 4,412.6	$ 3,953.6
Net income per share - basic (in dollars per share)	$ 43.07	$ 40.90	$ 37.05
Net income per share - diluted (in dollars per share)	$ 41.48	$ 38.34	$ 34.77
Weighted average shares outstanding - basic (in shares)	104.6	107.9	106.7
Weighted average shares outstanding - diluted (in shares)	108.6	115.1	113.7
Statements of Comprehensive Income
Net income	$ 4,504.9	$ 4,412.6	$ 3,953.6
Other comprehensive income (loss), net of tax:
Unrealized gain on debt securities	83.0	73.6	158.2
Gain (loss) on foreign currency translation	2.4	(0.6)	(0.3)
Comprehensive income	4,590.3	4,485.6	4,111.5
Net product sales
Revenues:
Revenue from contract with customer	6,309.1	7,629.2	7,078.0
Expenses:
Cost of goods sold and of collaboration and contract manufacturing	1,140.8	1,087.3	932.1
Collaboration revenue
Revenues:
Revenue from contract with customer	7,331.2	6,057.8	5,503.1
Other revenue
Revenues:
Revenue from contract with customer	702.6	515.0	536.1
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods sold and of collaboration and contract manufacturing	$ 959.9	$ 883.2	$ 883.7