CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024
Revenues:
Revenues	$ 3,754.3	$ 3,720.7	$ 10,458.6	$ 10,412.8
Expenses:
Research and development	1,475.0	1,271.5	4,224.1	3,719.9
Acquired in-process research and development	83.1	56.2	105.4	87.2
Selling, general, and administrative	657.8	714.4	1,925.0	2,162.2
Other operating (income) expense, net	(10.0)	8.0	(10.0)	37.9
Total Expenses	2,727.5	2,541.2	7,760.6	7,412.3
Income from operations	1,026.8	1,179.5	2,698.0	3,000.5
Other income (expense):
Other income (expense), net	755.8	327.3	1,520.6	866.0
Interest expense	(19.3)	(13.8)	(31.6)	(44.7)
Total other income (expense)	736.5	313.5	1,489.0	821.3
Income before income taxes	1,763.3	1,493.0	4,187.0	3,821.8
Income tax expense	303.3	152.4	526.7	326.9
Net income	$ 1,460.0	$ 1,340.6	$ 3,660.3	$ 3,494.9
Net income per share - basic (in dollars per share)	$ 14.09	$ 12.40	$ 34.83	$ 32.36
Net income per share - diluted (in dollars per share)	$ 13.62	$ 11.54	$ 33.61	$ 30.23
Weighted average shares outstanding - basic (in shares)	103.6	108.1	105.1	108.0
Weighted average shares outstanding - diluted (in shares)	107.2	116.2	108.9	115.6
Statements of Comprehensive Income
Net income	$ 1,460.0	$ 1,340.6	$ 3,660.3	$ 3,494.9
Other comprehensive income (loss), net of tax:
Unrealized gain on debt securities	15.7	128.2	75.9	139.6
Gain on foreign currency translation	0.8	1.9	1.0	1.5
Comprehensive income	1,476.5	1,470.7	3,737.2	3,636.0
Net product sales
Revenues:
Revenues	1,587.7	1,946.4	4,634.3	5,626.3
Expenses:
Cost of goods sold, collaboration and contract manufacturing	281.0	262.3	822.1	760.5
Collaboration revenue
Revenues:
Revenues	1,968.4	1,660.1	5,360.3	4,450.9
Other revenue
Revenues:
Revenues	198.2	114.2	464.0	335.6
Cost of collaboration and contract manufacturing
Expenses:
Cost of goods sold, collaboration and contract manufacturing	$ 240.6	$ 228.8	$ 694.0	$ 644.6