-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, SkxUc3iJo0xHRdCmAOnyQ+wrxIznlyuRcODnOvTyIsxJNJWslf7y+lxZigxtmo2R PZMsGd8+OSymA6QmbtgY8w== 0000891618-97-002530.txt : 19970610 0000891618-97-002530.hdr.sgml : 19970610 ACCESSION NUMBER: 0000891618-97-002530 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 19970522 ITEM INFORMATION: Other events ITEM INFORMATION: Financial statements and exhibits FILED AS OF DATE: 19970606 SROS: NASD FILER: COMPANY DATA: COMPANY CONFORMED NAME: CELTRIX PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000871395 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 943121462 STATE OF INCORPORATION: DE FISCAL YEAR END: 0331 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-18976 FILM NUMBER: 97620264 BUSINESS ADDRESS: STREET 1: 3055 PATRICK HENRY DR CITY: SANTA CLARA STATE: CA ZIP: 95054 BUSINESS PHONE: 4089882500 MAIL ADDRESS: STREET 2: 3055 PATRICK HENRY DRIVE CITY: SANTA CLARA STATE: CA ZIP: 95054 FORMER COMPANY: FORMER CONFORMED NAME: CELTRIX LABORATORIES INC DATE OF NAME CHANGE: 19600201 8-K 1 FORM 8-K 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: May 22, 1997 Commission File Number: 0-18976 CELTRIX PHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) DELAWARE 94-3121462 (State or other jurisdiction (I.R.S. Employer Identification No.) of incorporation or organization) 3055 Patrick Henry Drive, Santa Clara, CA 95054-1815 (Address of principal executive offices and zip code) Registrant's Telephone Number: (408) 988-2500 2 ITEM 5. OTHER EVENTS On May 22, 1997, Celtrix Pharmaceuticals, Inc., a Delaware corporation (the "Company") announced it has received two new patents from the U.S. Patent and Trademark Office. Further details regarding this announcement are contained in the Company's news release dated May 22, 1997, attached as exhibit hereto and incorporated by reference herein. ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS (A) EXHIBITS Exhibit 21 Celtrix Pharmaceuticals, Inc. News Release dated May 22, 1997. 3 SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. CELTRIX PHARMACEUTICALS, INC. (Registrant) Date: June 4, 1997 By: /s/ MARY ANNE RIBI ---------------------------------------- Mary Anne Ribi Vice President, Finance & Administration and Chief Financial Officer (Duly authorized principal financial and accounting officer) 4 CELTRIX PHARMACEUTICALS, INC. INDEX TO EXHIBITS Exhibit Number Exhibit 21 Celtrix Pharmaceuticals, Inc. Press Release dated May 22, 1997. EX-21 2 CELTRIX PHARMACEUTICALS, INC. PRESS RELEASE 1 EXHIBIT 21 [LOGO] NEWS RELEASE CONTACT: David M. Rosen, Ph.D. Vice President, Research and Development [Letterhead] (408) 988-2500 CELTRIX RECEIVES TWO ADDITIONAL U.S. PATENTS SANTA CLARA, CA -- May 22, 1997 -- Celtrix Pharmaceuticals, Inc. (Nasdaq: CTRX) announced today that it has received two additional patents from the United States Patent and Trademark Office, further protecting its proprietary technology relating to the production and use of SomatoKine(R), the company's novel IGF-BP3 complex. SomatoKine is currently undergoing early-stage Phase II human clinical testing. U.S. Patent No. 5,629,172, entitled "Expression of Fusion Polypeptides Transported Out of the Cytoplasm Without Leader Sequences," relates to recombinant protein production using fusion protein technology. The new patent, which is related to U.S. Patent No. 5,563,046 issued to Celtrix last year, claims compositions and methods involving fusion proteins which use variants of the bacterial proteins DsbA and DsbC as fusion partners. The claimed compositions and methods are generally applicable to the production of recombinant proteins and may also be useful in the manufacture of SomatoKine. U.S. Patent No. 5,624,805, entitled "Uses for Antibodies Which Bind to Human Somatomedin Carrier Protein Subunits," was issued with claims relating to the use of antibodies to an insulin-like growth factor (IGF) binding protein in methods for determining levels of free (unbound) IGF. Celtrix is a biopharmaceutical company developing novel therapeutics for the treatment of seriously debilitating, degenerative conditions primarily associated with severe trauma, chronic diseases or aging. The company's focus is on SomatoKine, a novel IGF-BP3 complex, for use in regenerating lost muscle, bone and other tissues essential for the patient's health and quality of life. Initial product development programs target acute traumatic injury, such as hip fracture surgery in the elderly, and severe burns. Other potential indications include severe osteoporosis and protein wasting diseases associated with cancer, AIDS and other life-threatening conditions. Through strategic alliances with Celtrix, The Green Cross Corporation is developing SomatoKine for the treatment of osteoporosis in Japan, and Genzyme Corporation is developing TGF-beta-2 as part of a comprehensive approach to tissue repair and the treatment of systemic disease. This news release contains certain forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Actual results may differ materially from the statements made, as a result of various factors, including risks associated with unforeseen interference proceedings related to these new patents, ability of third parties to engineer or develop processes or products around these patent claims, future company research, clinical study results, the regulatory approval process, competitive products and other factors which are listed from time to time in Celtrix's Securities and Exchange Commission (SEC) filings. These forward-looking statements represent Celtrix's judgment as of the date of this news release. -end- -----END PRIVACY-ENHANCED MESSAGE-----