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Business and Organization (Details)
$ in Thousands
Apr. 28, 2023
Jan. 17, 2023
Sep. 27, 2022
USD ($)
Oct. 25, 2021
USD ($)
Mar. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Organization Consolidation And Presentation Of Financial Statements [Line Items]            
Accumulated deficit         $ 780,688 $ 758,821
Cash, cash equivalents and investments         $ 2,100  
Percentage of positions eliminated 80.00%          
Reverse stock split conversion ratio   0.059        
NovaQuest            
Organization Consolidation And Presentation Of Financial Statements [Line Items]            
Maximum amount agreed to be paid by related party       $ 35,000    
Proceeds from sale of common stock and warrants       15,000    
Capital contributions committed       $ 20,000    
Proceeds from related party     $ 20,000      
Interest rate       12.00%