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The amount of transaction price of the contract under the collaborative arrangement.

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The upfront, non-refundable, non-creditable cash payment received under the collaboration agreement.

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Amount of investment in equity security without readily determinable fair value.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

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Amount of transaction price allocated to performance obligation that has not been recognized as revenue.

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Indicates type of revenue from product and service. Includes, but is not limited to, revenue from contract with customer and other sources.

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Collaboration and License Agreements (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended
	Feb. 28, 2021	Apr. 30, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Alliance revenue					$ 1,448
Revenue, Product and Service [Extensible List]			us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Research and development			$ 16,375	$ 24,772	$ 34,853
Option and License Agreement with Licensee
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Transaction price			1,400
Performance obligation			$ 0
Percentage of shares acquired		10.00%	10.00%
Option and License Agreement with Licensee \| Other Assets
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Value of securities without a readily determinable fair value			$ 100
Scriptr Global, Inc. \| Research and Development Plans and Designation of Development Candidates [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Research and development			$ 2,100
Scriptr Global, Inc. \| Maximum [Member] \| Research and Development Plans and Designation of Development Candidates [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Deferred revenue recognition period	270 days
IMO-9200 License \| Option and License Agreement with Licensee
Collaborative Arrangements and Non-collaborative Arrangement Transactions
Upfront payment received under collaboration agreement		$ 1,400