Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2020

Stock-Based Compensation

Schedule of stock-based compensation expense attributable to share-based payments made to employees and directors and included in operating expenses

	Three Months Ended
	March 31,
(in thousands)	2020		2019
Stock-based compensation:
Research and development
Employee Stock Purchase Plans	$	11	$	6
Equity Incentive Plans		193		330
	$	204	$	336
General and administrative
Employee Stock Purchase Plans	$	1	$	6
Equity Incentive Plans		545		674
	$	546	$	680
Total stock-based compensation expense	$	750	$	1,016

Schedule of weighted average assumptions applied to options

	Three Months Ended
	March 31,
	2020		2019
Average risk-free interest rate		1.6%		2.4%
Expected dividend yield		—		—
Expected lives (years)		3.8		3.6
Expected volatility		82.7%		82.0%
Weighted average exercise price (per share)	$	1.80	$	3.14

Schedule of information related to outstanding and exercisable options

($ in thousands, except per share data)	Stock Options	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value
Outstanding at December 31, 2019	4,220,417	$	13.08	6.6	$
Granted	643,629		1.80
Exercised	—		—
Forfeited	(38,874)		5.67
Expired	(120,080)		19.73
Outstanding at March 31, 2020 (1)	4,705,092	$	11.43	7.0	$	—
Exercisable at March 31, 2020	2,373,804	$	18.16	4.9	$	—

(1) Includes both vested stock options as well as unvested stock options for which the requisite service period has not been rendered but that are expected to vest based on achievement of a service condition.

Schedule of summary of restricted stock activity

($ in thousands, except per share data)	Number of Shares	Weighted-Average Grant Date Fair Value
Nonvested shares at December 31, 2019	193,625	$	3.14
Granted	237,675		1.79
Cancelled	(6,688)		2.34
Vested	(48,402)		3.14
Nonvested shares at March 31, 2020	376,210	$	2.30