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Business and Organization (Details)
$ in Thousands
Jul. 27, 2018
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Business and Organization      
Accumulated deficit   $ 720,890 $ 664,375
Cash, cash equivalents and investments   42,800  
Contingently refundable option fee received in connection with Private Placement   $ 6,200  
Reverse stock split conversion ratio 0.125