Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130545-203045

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130543-203045

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

Alliance Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
Alliance Revenue (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Alliance Revenue
Alliance revenue	$ 1,448	$ 163	$ 1,448	$ 418
Out-license arrangement (1)
Alliance Revenue
Alliance revenue	1,447		1,447
Gsk Collaboration
Alliance Revenue
Alliance revenue		141		283
Vivelix Collaboration
Alliance Revenue
Alliance revenue				56
Other
Alliance Revenue
Alliance revenue	$ 1	$ 22	$ 1	$ 79