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CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS        
Alliance revenue $ 1,448 $ 163 $ 1,448 $ 418
Revenue, Product and Service [Extensible List] us_gaap:RevenueFromContractWithCustomerIncludingAssessedTax us_gaap:RevenueFromContractWithCustomerIncludingAssessedTax us_gaap:RevenueFromContractWithCustomerIncludingAssessedTax us_gaap:RevenueFromContractWithCustomerIncludingAssessedTax
Operating expenses:        
Research and development $ 10,024 $ 10,880 $ 18,126 $ 24,436
General and administrative 2,895 4,000 6,038 7,481
Merger-related costs, net   1,583   5,081
Restructuring costs 45   176  
Total operating expenses 12,964 16,463 24,340 36,998
Loss from operations (11,516) (16,300) (22,892) (36,580)
Other income (expense):        
Interest income 339 271 743 482
Interest expense   (4)   (11)
Foreign currency exchange loss 1 2 (1) (17)
Net loss $ (11,176) $ (16,031) $ (22,150) $ (36,126)
Net loss per share applicable to common stockholders - basic and diluted (Note 13) $ (0.39) $ (0.59) $ (0.79) $ (1.39)
Weighted-average number of common shares used in computing net loss per share applicable to common stockholders - basic and diluted 28,461 27,133 28,070 26,012
Comprehensive loss:        
Net loss $ (11,176) $ (16,031) $ (22,150) $ (36,126)
Unrealized gain on available-for-sale securities     2  
Total other comprehensive income     2  
Comprehensive loss $ (11,176) $ (16,031) $ (22,148) $ (36,126)