XML 65 R46.htm IDEA: XBRL DOCUMENT v3.10.0.1
Stock-Based Compensation - Accounting for Stock-based Compensation (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award        
Percentage of share-based compensation expense     15.00%  
Weighted average grant date fair value of options granted during the period (per share)     $ 7.15 $ 8.08
Stock-based compensation $ 1,327 $ 1,623 $ 4,454 $ 9,165
Research and development        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 314 589 1,441 5,972
Research and development | Employee Stock Purchase Plans        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 11 26 62 68
Research and development | Equity Incentive Plans        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 303 563 1,379 5,904
General and administrative        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 989 1,034 2,989 3,193
General and administrative | Employee Stock Purchase Plans        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 8 18 40 48
General and administrative | Equity Incentive Plans        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation 981 $ 1,016 2,949 $ 3,145
Restructuring costs | Employee Stock Purchase Plans        
Share-based Compensation Arrangement by Share-based Payment Award        
Stock-based compensation $ 24   $ 24