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Related Party Transactions - Overview of Related Parties (Details) - USD ($)
$ / shares in Units, $ in Millions
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Related Party Transactions      
Number of Warrants 2,768,882   5,469,673
Exercise price of warrants $ 0.08   $ 1.90
Common stock issued in lieu of board fees 4,727 4,818  
Maximum      
Related Party Transactions      
Proceeds from issuance of common stock in lieu of director board and committee fees $ 0.1 $ 0.1  
Common Stock | Board of Director      
Related Party Transactions      
Ownership percentage 18.00%    
Pillar Investment Entities | Common Stock      
Related Party Transactions      
Ownership percentage 12.00%    
Besancon      
Related Party Transactions      
Proceeds from exercise of warrants $ 0.6    
Number of Warrants 150,000    
Exercise price of warrants $ 3.76    
Baker Bros. Advisors LP      
Related Party Transactions      
Number of warrants exercised 2,539,541    
Proceeds from exercise of warrants $ 9.5    
Exercise price of warrants $ 3.76    
Baker Bros. Advisors LP | Pre-funded Warrants      
Related Party Transactions      
Number of Warrants 2,768,882    
Exercise price of warrants $ 0.08