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CONDENSED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Cash Flows from Operating Activities:    
Net loss $ (20,095) $ (15,057)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 1,589 1,784
Issuance of common stock for services rendered 23 43
Accretion of discounts and premiums on investments   74
Depreciation and amortization expense 169 176
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,341 (2,205)
Accounts payable, accrued expenses, and other liabilities 2,416 (2,183)
Deferred revenue (190) (278)
Net cash used in operating activities (14,747) (17,646)
Cash Flows from Investing Activities:    
Proceeds from maturity of available-for-sale securities   16,720
Purchases of property and equipment (14) (30)
Net cash (used in) provided by investing activities (14) 16,690
Cash Flows from Financing Activities:    
Proceeds from employee stock purchases 81 57
Proceeds from exercise of common stock warrants 9,591  
Payments on note payable (78) (70)
Payments on capital lease (3) (4)
Net cash provided by (used in) financing activities 9,591 (17)
Net decrease in cash, cash equivalents and restricted cash (5,170) (973)
Cash, cash equivalents and restricted cash, beginning of period 112,940 80,978
Cash, cash equivalents and restricted cash, end of period $ 107,770 $ 80,005